Art

J-GLOBAL ID：202102231586869520   Reference number：21A1358850

Relevance of SIRT1-NF-κB Axis as Therapeutic Target to Ameliorate Inflammation in Liver Disease

肝疾患における炎症を改善する治療標的としてのSIRT1-NF-κBAxisの関連性【JST・京大機械翻訳】

Author (4)： Gregorio Estefania de (Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain) ,  Colell Anna (Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, Centro de Investigacion Biomedica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), 08036 Barcelona, Spain) ,  Morales Albert (Department of Cell Death and Proliferation, IIBB-CSIC, Barcelona Clinic Liver Cancer Group, Liver Unit, Hospital Clinic of Barcelona, University of Barcelona, CIBEREHD, 08036 Barcelona, Spain) ,  Mari Montserrat (Department of Cell Death and Proliferation, IIBB-CSIC, IDIBAPS, 08036 Barcelona, Spain)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 21  Issue： 11  Page： 3858  Publication year： 2020 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Inflammation is an adaptive re...

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Thesaurus term： *inflammation ,  hepatitis ,  liver cirrhosis ,  *liver disease ,  homeostasis ,  targeting ,  hepatoma ,  pathological state ,  transcription factor ,  histone deacetylase
Semi thesaurus term： 非アルコール性脂肪性肝炎 ,  炎症反応 ,  非アルコール性脂肪性肝疾患 ,  *治療標的 ,  組織損傷 , 【Automatic Indexing@JST】

Author keywords (10)： SIRT1 ,  NF-κB ,  inflammation ,  liver ,  NAFLD ,  cathepsins ,  AMPK ,  PPAR ,  NAD⁺ ,  STACs

JST classification (2)： Digestive system diseases  (GH03000W) ,  Basic medicine on digestive system  (GH01020E)

Reference (180)：

• Imai, S.; Armstrong, C.M.; Kaeberlein, M.; Guarente, L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000, 403, 795-800.
• Frye, R.A. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochem. Biophys. Res. Commun. 2000, 273, 793-798.
• Alves-Fernandes, D.K.; Jasiulionis, M.G. The Role of SIRT1 on DNA Damage Response and Epigenetic Alterations in Cancer. Int. J. Mol. Sci. 2019, 20, 3153.
• Blander, G.; Guarente, L. The Sir2 family of protein deacetylases. Annu. Rev. Biochem. 2004, 73, 417-435.
• Ong, A.L.C.; Ramasamy, T.S. Role of Sirtuin1-p53 regulatory axis in aging, cancer and cellular reprogramming. Ageing Res. Rev. 2018, 43, 64-80.

Terms in the title (5)： 肝疾患 ,  炎症 ,  治療標的 ,  SIRT1 ,  関連性