Art

J-GLOBAL ID：202102232552467526   Reference number：21A1883830

Severe Candida glabrata pancolitis and fatal Aspergillus fumigatus pulmonary infection in the setting of bone marrow aplasia after CD19-directed CAR T-cell therapy - a case report

CD19指向性CAR T細胞療法後の骨髄形成不全の環境における重篤なCandida glabrata腸炎と致命的Aspergillus fumigatus肺感染 症例報告【JST・京大機械翻訳】

Author (22)： Rejeski Kai (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Rejeski Kai (Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany) ,  Rejeski Kai (German Cancer Consortium (DKTK) and German Cancer Research Center, Heidelberg, Germany) ,  Kunz Wolfgang G. (Department of Radiology, University Hospital, LMU Munich, Munich, Germany) ,  Rudelius Martina (Department of Pathology, University Hospital, LMU Munich, Munich, Germany) ,  Buecklein Veit (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Buecklein Veit (Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany) ,  Blumenberg Viktoria (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Blumenberg Viktoria (Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany) ,  Schmidt Christian (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Karschnia Philipp (Department of Neurosurgery, University Hospital, LMU Munich, Munich, Germany) ,  Schoberl Florian (Department of Neurology, University Hospital, LMU Munich, Munich, Germany) ,  Dimitriadis Konstantin (Department of Neurology, University Hospital, LMU Munich, Munich, Germany) ,  Baumgarten Louisa von (Department of Neurology, University Hospital, LMU Munich, Munich, Germany) ,  Stemmler Joachim (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Weigert Oliver (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Dreyling Martin (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Bergwelt-Baildon Michael von (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Bergwelt-Baildon Michael von (German Cancer Consortium (DKTK) and German Cancer Research Center, Heidelberg, Germany) ,  Subklewe Marion (Department of Hematology and Oncology, University Hospital, LMU Munich, Munich, Germany) ,  Subklewe Marion (Laboratory for Translational Cancer Immunology, LMU Gene Center, Munich, Germany) ,  Subklewe Marion (German Cancer Consortium (DKTK) and German Cancer Research Center, Heidelberg, Germany)
Material： BMC Infectious Diseases (Web)
Volume： 21  Issue： 1  Page： 1-8  Publication year： 2021 
JST Material Number： U7430A  ISSN： 1471-2334  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Prolonged myelosuppression fol...

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Thesaurus term： *bone marrow ,  adrenocortical hormone ,  immunosuppressant ,  *Candida ,  hemopoiesis ,  drug therapy ,  immunosuppression ,  blood transfusion ,  metabasis ,  stem cell ,  neutropenia ,  respiratory insufficiency ,  case report ,  therapeutic planning ,  *cell transplantation
Semi thesaurus term： *CD19抗原 , 【Automatic Indexing@JST】

Author keywords (5)： CAR T-cell ,  Case report ,  Hematotoxicity ,  Candida glabrata ,  Invasive aspergillosis

JST classification (3)： Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Treatment for infectious diseases,parasitic diseases.  (GD01030D) ,  Blood cell tumors(=neoplasms)  (GK04000M)

Reference (26)：

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• Biol Blood Marrow Transplant; Late Events after Treatment with CD19-Targeted Chimeric Antigen Receptor Modified T Cells; A Cordeiro, ED Bezerra, AV Hirayama, JA Hill, QV Wu, J Voutsinas; 26; 1; 2020; 26-33; 10.1016/j.bbmt.2019.08.003; citation_id=CR2
• Bone Marrow Transplant; Early and late hematologic toxicity following CD19 CAR-T cells; S Fried, A Avigdor, B Bielorai, A Meir, MJ Besser, J Schachter; 54; 10; 2019; 1643-1650; 10.1038/s41409-019-0487-3; citation_id=CR3
• N Engl J Med; Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma; SJ Schuster, MR Bishop, CS Tam, EK Waller, P Borchmann, MG JP; 380; 1; 2019; 45-56; 10.1056/NEJMoa1804980; citation_id=CR4
• Lancet Oncol; Long-term safety and activity of axicabtagene ciloleucel in refractory large B-cell lymphoma (ZUMA-1): a single-arm, multicentre, phase 1-2 trial; FL Locke, A Ghobadi, CA Jacobson, DB Miklos, LJ Lekakis, OO Oluwole; 20; 1; 2019; 31-42; 10.1016/S1470-2045(18)30864-7; citation_id=CR5

Terms in the title (12)： CD19 ,  指向性 ,  T細胞療法 ,  骨 ,  髄形成不全 ,  環境 ,  Candida ,  腸炎 ,  Aspergillus ,  肺 ,  感染 ,  症例報告