Art

J-GLOBAL ID：202102233520838578   Reference number：21A0131929

A Case Report of a Non-small-cell Lung Cancer Patient Who Was EGFR-negative on a Conventional Test but Was Discovered to Have an EGFR Uncommon Mutation on Comprehensive Genomic Profiling and Responded to Afatinib

当初EGFR遺伝子変異陰性であったが,遺伝子パネル検査でuncommon mutationが検出されアファチニブが奏効した非小細胞肺癌の1例

Author (7)： ENDO SHUN (東京医科歯科大学呼吸器内科) ,  MITSUMURA TAKAHIRO (東京医科歯科大学呼吸器内科) ,  ISHIZUKA MASAHIRO (東京医科歯科大学呼吸器内科) ,  HONDA TAKAYUKI (東京医科歯科大学呼吸器内科) ,  SAKAKIBARA RIE (東京医科歯科大学呼吸器内科) ,  IKEDA SADAKATSU (東京医科歯科大学がん先端治療部がんゲノム診療科) ,  MIYAZAKI YASUNARI (東京医科歯科大学呼吸器内科)
Material： 肺癌(Web)  (Japanese Journal of Lung Cancer (Web))
Volume： 60  Issue： 5  Page： 429-433(J-STAGE)  Publication year： 2020 
JST Material Number： U0408A  ISSN： 1348-9992  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *non-small cell lung cancer ,...
Semi thesaurus term： *EGFR gene ,...

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Author keywords (10)： EGFR遺伝子変異陽性非小細胞肺癌 ,  EGFR uncommon mutation ,  がん遺伝子パネル検査 ,  PNA LNA PCR-Clamp法 ,  アファチニブ ,  EGFR mutation-positive non-small-cell lung cancer ,  EGFR uncommon mutation ,  Tumor profiling test ,  PNA LNA PCR-Clamp method ,  Afatinib

JST classification (3)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Drug therapy(=pharmacotherapy)for tumors  (GE03032C) ,  Genetic variation  (EC01030Y)

Substance index (1)： Afatinib

Reference (13)：

• 1. Jameson JL, Longo DL. Precision medicine--personalized, problematic, and promising. N Engl J Med. 2015; 372: 2229-2234.
• 2. Zehir A, Benayed R, Shah RH, Syed A, Middha S, Kim HR, et al. Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients. Nat Med. 2017; 23: 703-713.
• 3. Lindeman NI, Cagle PT, Aisner DL, Arcila ME, Beasley MB, Bernicker EH, et al. Updated Molecular Testing Guideline for the Selection of Lung Cancer Patients for Treatment With Targeted Tyrosine Kinase Inhibitors: Guideline From the College of American Pathologists, the International Association for the Study of Lung Cancer, and the Association for Molecular Pathology. J Thorac Oncol. 2018; 13: 323-358.
• 4. 日本肺癌学会バイオマーカー委員会. 肺癌患者におけるEGFR遺伝子変異検査の手引き (第4.2版). 2019.
• 5. Beau-Faller M, Prim N, Ruppert AM, Nanni-Metéllus I, Lacave R, Lacroix L, et al. Rare EGFR exon 18 and exon 20 mutations in non-small-cell lung cancer on 10117 patients: a multicentre observational study by the French ERMETIC-IFCT network. Ann Oncol. 2014; 25: 126-131.

Terms in the title (4)： EGFR遺伝子変異 ,  遺伝子パネル検査 ,  アファチニブ ,  非小細胞肺癌