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J-GLOBAL ID：202102234778982997   Reference number：21A0348688

The ER cholesterol sensor SCAP promotes CARTS biogenesis at ER-Golgi membrane contact sites

ERコレステロールセンサーSCAPはER-ゴルジ膜接触部位でのCARTS生合成を促進する【JST・京大機械翻訳】

Author (14)： Wakana Yuichi (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Hayashi Kaito (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Nemoto Takumi (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Watanabe Chiaki (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Taoka Masato (Faculty of Science, Department of Chemistry, Tokyo Metropolitan University, Hachioji, Tokyo, Japan) ,  Angulo-Capel Jessica (Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain) ,  Garcia-Parajo Maria F. (Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain) ,  Garcia-Parajo Maria F. (Institucio Catalana de Recerca i Estudis Avancats, Barcelona, Spain) ,  Kumata Hidetoshi (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Umemura Tomonari (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Inoue Hiroki (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Arasaki Kohei (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan) ,  Campelo Felix (Institut de Ciencies Fotoniques, The Barcelona Institute of Science and Technology, Barcelona, Spain) ,  Tagaya Mitsuo (School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan)
Material： Journal of Cell Biology  (JCB)
Volume： 220  Issue： 1  Page： Null  Publication year： 2020 
JST Material Number： C0575A  ISSN： 0021-9525  CODEN： JCLBA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： In response to cholesterol dep...

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Thesaurus term： interaction ,  *biosynthesis ,  Golgi body ,  Endoplasmic Reticulum ,  phosphatase ,  subcellular distribution ,  complex (substance) ,  turnover ,  gene expression ,  wild type ,  transcription factor ,  *SCAP ,  lipid transfer ,  cholesterol synthesis ,  molecular genetic phenomenon ,  sterol ,  alicyclic alcohol

JST classification (2)： Cell physiology in general  (EF02010S) ,  Function of cell components  (EF03060C)

Substance index (1)： Cholesterol

Reference (82)：

• Adams. Cholesterol-induced conformational change in SCAP enhanced by Insig proteins and mimicked by cationic amphiphiles. Proc. Natl. Acad. Sci. USA. 2003, 100, 10647. doi:10.1073/pnas.1534833100
• Adams. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J. Biol. Chem. 2004, 279, 52772. doi:10.1074/jbc.M410302200
• Antonny. The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol. Annu. Rev. Biochem. 2018, 87, 809. doi:10.1146/annurev-biochem-061516-044924
• Baron. Role of diacylglycerol in PKD recruitment to the TGN and protein transport to the plasma membrane. Science. 2002, 295, 325. doi:10.1126/science.1066759
• Blagoveshchenskaya. Integration of Golgi trafficking and growth factor signaling by the lipid phosphatase SAC1. J. Cell Biol. 2008, 180, 803. doi:10.1083/jcb.200708109

Terms in the title (7)： Er ,  コレステロール ,  センサー ,  SCAP ,  接触部 ,  生合成 ,  促進