Art

J-GLOBAL ID：202102237385253266   Reference number：21A0829601

PPAR Beta/Delta and the Hallmarks of Cancer

PPARβ/デルタと癌の特徴【JST・京大機械翻訳】

Author (2)： Wagner Nicole ,  Wagner Kay-Dietrich
Material： Cells (Web)
Volume： 9  Issue： 5  Page： 1133  Publication year： 2020 
JST Material Number： U7155A  ISSN： 2073-4409  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Peroxisome proliferator-activa...

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Thesaurus term： receptor ,  tumor cell ,  diabetes mellitus ,  clinical trial ,  hyperlipidemia ,  in vitro experiment ,  PPAR gamma ,  PPAR alpha ,  *metabolic syndrome
Semi thesaurus term： アゴニスト ,  コアクチベータ ,  アンタゴニスト ,  コリプレッサー ,  標的遺伝子 ,  治療標的 , 【Automatic Indexing@JST】

Author keywords (9)： peroxisome proliferator-activated receptor ,  angiogenesis ,  proliferation ,  metastasis ,  immortality ,  resistance to cell death ,  growth suppressors ,  immune system ,  cellular metabolism

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q)

Reference (187)：

• Wagner, K.D.; Wagner, N. Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) acts as regulator of metabolism linked to multiple cellular functions. Pharmacol. Ther. 2010, 125, 423-435.
• Lefebvre, P.; Chinetti, G.; Fruchart, J.C.; Staels, B. Sorting out the roles of PPAR alpha in energy metabolism and vascular homeostasis. J. Clin. Investig. 2006, 116, 571-580.
• Takada, I.; Makishima, M. Peroxisome proliferator-activated receptor agonists and antagonists: A patent review (2014-present). Expert Opin. Ther. Pat. 2020, 30, 1-13.
• Cheng, H.S.; Tan, W.R.; Low, Z.S.; Marvalim, C.; Lee, J.Y.H.; Tan, N.S. Exploration and Development of PPAR Modulators in Health and Disease: An Update of Clinical Evidence. Int. J. Mol. Sci. 2019, 20, 5055.
• Xi, Y.; Zhang, Y.; Zhu, S.; Luo, Y.; Xu, P.; Huang, Z. PPAR-Mediated Toxicology and Applied Pharmacology. Cells 2020, 9, 352.

Terms in the title (3)： PPARβ ,  デルタ ,  癌