Art

J-GLOBAL ID：202102239505191496   Reference number：21A1907560

Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment

血漿グリア線維性酸性蛋白質は,軽度認知障害患者におけるアルツハイマー病病理を検出し,アルツハイマー型認知症への将来の転換を予測する【JST・京大機械翻訳】

Author (15)： Cicognola Claudia (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ,  Cicognola Claudia (Memory Clinic, Skane University Hospital, Malmo, Sweden) ,  Janelidze Shorena (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ,  Hertze Joakim (Memory Clinic, Skane University Hospital, Malmo, Sweden) ,  Zetterberg Henrik (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden) ,  Zetterberg Henrik (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden) ,  Zetterberg Henrik (Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK) ,  Zetterberg Henrik (UK Dementia Research Institute at UCL, London, UK) ,  Blennow Kaj (Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, The Sahlgrenska Academy at the University of Gothenburg, Molndal, Sweden) ,  Blennow Kaj (Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Molndal, Sweden) ,  Mattsson-Carlgren Niklas (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ,  Mattsson-Carlgren Niklas (Department of Neurology, Skane University Hospital, Lund, Sweden) ,  Mattsson-Carlgren Niklas (Wallenberg Center for Molecular Medicine, Lund University, Lund, Sweden) ,  Hansson Oskar (Clinical Memory Research Unit, Department of Clinical Sciences, Lund University, Lund, Sweden) ,  Hansson Oskar (Memory Clinic, Skane University Hospital, Malmo, Sweden)
Material： Alzheimer's Research & Therapy (Web)
Volume： 13  Issue： 1  Page： 1-9  Publication year： 2021 
JST Material Number： U7297A  ISSN： 1758-9193  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Plasma glial fibrillary acidic...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A1907560&from=J-GLOBAL&jstjournalNo=U7297A") }}

Thesaurus term： *plasma(blood) ,  amyloid ,  cerebrospinal fluid ,  population(statistics) ,  base line ,  *Alzheimer disease ,  *pathological state ,  astrocyte ,  biomarker ,  follow-up study ,  apo E ,  *dementia
Semi thesaurus term： アミロイドβ42 ,  *軽度認知障害 ,  予測因子 , 【Automatic Indexing@JST】

Author keywords (4)： Blood biomarkers ,  GFAP ,  Alzheimer’s disease ,  Mild cognitive impairment

JST classification (1)： Neurologic diagnosis  (GN02000H)

Reference (42)：

• Global Dementia Observatory, Global action plan on the public health response to dementia 2017-2025; 2017; citation_id=CR1
• Lancet Neurol; Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer’s disease in the presenilin 1 E280A kindred: a case-control study; EM Reiman, YT Quiroz, AS Fleisher, K Chen, C Velez-Pardo, M Jimenez-Del-Rio; 11; 12; 2012; 1048-1056; 10.1016/S1474-4422(12)70228-4; citation_id=CR2
• Prog Neurobiol; Astrogliosis: an integral player in the pathogenesis of Alzheimer’s disease; LM Osborn, W Kamphuis, WJ Wadman, EM Hol; 144; 2016; 121-141; 10.1016/j.pneurobio.2016.01.001; citation_id=CR3
• Plos One; A reduced astrocyte response to beta-amyloid plaques in the ageing brain associates with cognitive impairment; R Mathur, PG Ince, T Minett, CJ Garwood, PJ Shaw, FE Matthews, C Brayne, JE Simpson, SB Wharton; 10; 2; 2015; e0118463; 10.1371/journal.pone.0118463; citation_id=CR4
• Cell Death Dis; Astrocytes are important mediators of Aβ-induced neurotoxicity and tau phosphorylation in primary culture; CJ Garwood, AM Pooler, J Atherton, DP Hanger, W Noble; 2; 6; 2011; e167-e; 10.1038/cddis.2011.50; citation_id=CR5

Terms in the title (9)： 血漿 ,  グリア線維性酸性蛋白質 ,  軽度認知障害 ,  患者 ,  アルツハイマー病 ,  病理 ,  アルツハイマー型認知症 ,  転換 ,  予測