Art

J-GLOBAL ID：202102239777056511   Reference number：21A0344968

Combined use of chemically modified nucleobases and nanostructured DNA for enhanced immunostimulatory activity of CpG oligodeoxynucleotide

CpGオリゴデオキシヌクレオチドの免疫刺激活性増強のための化学修飾核酸塩基とナノ構造DNAの組み合わせ利用【JST・京大機械翻訳】

Author (11)： Araie Yuki (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Ohtsuki Shozo (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Park Soyoung (Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan) ,  Nagaoka Makoto (Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278-8510, Japan) ,  Umemura Keisuke (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Sugiyama Hiroshi (Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan) ,  Sugiyama Hiroshi (Institute for Integrated Cell-Material Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Kusamori Kosuke (Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278-8510, Japan) ,  Takahashi Yuki (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Takakura Yoshinobu (Department of Biopharmaceutics and Drug Metabolism, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyo-ku, Kyoto 606-8501, Japan) ,  Nishikawa Makiya (Laboratory of Biopharmaceutics, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Chiba 278-8510, Japan)
Material： Bioorganic & Medicinal Chemistry  (Bioorganic and Medicinal Chemistry)
Volume： 29  Page： Null  Publication year： 2021 
JST Material Number： W0556A  ISSN： 0968-0896  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Oligodeoxynucleotide (ODN) con...

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Thesaurus term： donor ,  phosphate ,  *DNA ,  allergic reaction ,  *nucleic acid base ,  side effect ,  base pair substitution ,  *nanostructure ,  TNF alpha ,  RAW264.7 cell ,  aggregate ,  nitrogen heterocyclic compound ,  hydroxy compound
Semi thesaurus term： *オリゴデオキシヌクレオチド ,  *CpG ,  *CpG-ODN , 【Automatic Indexing@JST】

Author keywords (5)： CpG DNA ,  Chemical modification ,  Nucleobases ,  ^thdG ,  Nucleic acid therapeutics

JST classification (2)： Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Synthesis of drugs  (GV01030F)

Substance index (1)： Guanine

Terms in the title (9)： CpGオリゴデオキシヌクレオチド ,  免疫刺激 ,  活性 ,  増強 ,  化学修飾 ,  核酸塩基 ,  ナノ構造 ,  DNA ,  組み合わせ