Art

J-GLOBAL ID：202102240440424300   Reference number：21A0168708

Syntheses and Evaluation of 2- or 3-(N-Cyclicamino)chromone Derivatives as Monoamine Oxidase Inhibitors

モノアミンオキシダーゼ阻害剤としての2-または3-(N-環状アミノ)クロモン誘導体の合成および評価

Author (4)： Takao Koichi (Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Sakatsume Tsukasa (Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Kamauchi Hitoshi (Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University) ,  Sugita Yoshiaki (Laboratory of Bioorganic Chemistry, Department of Pharmaceutical Sciences, Faculty of Pharmacy and Pharmaceutical Sciences, Josai University)
Material： Chemical and Pharmaceutical Bulletin (Web)
Volume： 68  Issue： 11  Page： 1082-1089(J-STAGE)  Publication year： 2020 
JST Material Number： U1401A  ISSN： 1347-5223  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： ketone ,...
Semi thesaurus term： Chromones ,...

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Author keywords (10)： 2-(N-cycloamino)chromone ,  3-(N-cycloamino)chromone ,  monoamine oxidase (MAO) ,  structure-activity relationship ,  molecular docking analysis ,  2-(N-cycloamino)chromone ,  3-(N-cycloamino)chromone ,  monoamine oxidase (MAO) ,  structure-activity relationship ,  molecular docking analysis

JST classification (3)： Structure-activity relationship of drugs  (GV01050B) ,  Basic research of enzyme preparations and enzyme inhibitor preparations  (GW21010W) ,  Condensed derivatives of pyrane  (CF07093I)

Substance index (2)： 3-(4-phenylpiperazin-1-yl)chromen-4-one ,  7-methoxy-3-(4-phenylpiperazin-1-yl)chromen-4-one

Reference (34)：

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• 3) Tipton K. F. J. Neural., Transm. (Vienna), 125, 1519-1551 (2018).
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• 5) Hou Y., Dan X., Babbar M., Wei Y., Hasselbalch S. G., Croteau D. L., Bohr V. A., Nat. Rev. Neurol., 15, 565-581 (2019).

Terms in the title (4)： モノアミンオキシダーゼ阻害剤 ,  環状 ,  クロモン誘導体 ,  評価