Art

J-GLOBAL ID：202102240973575685   Reference number：21A2437961

Evaluation of Dissolution Profiles of a Newly Developed Solid Oral Immediate-Release Formula Containing Alpha-Lipoic Acid

α-リポ酸を含む新たに開発した固体経口即時放出製剤の溶出プロファイルの評価【JST・京大機械翻訳】

Author (12)： Pop Anca Lucia (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania) ,  Crisan Simona (RD Center, AC HELCOR, Victor Babes St., 430082 Baia Mare, Romania) ,  Barca Maria (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania) ,  Ciobanu Anne-Marie (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania) ,  Varlas Valentin Nicolae (Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, 030167 Bucharest, Romania) ,  Pop Coriolan (RD Center, AC HELCOR, Victor Babes St., 430082 Baia Mare, Romania) ,  Pali Mariana-Ana (RD Center, AC HELCOR, Victor Babes St., 430082 Baia Mare, Romania) ,  Cauni Dumitru (RD Center, AC HELCOR, Victor Babes St., 430082 Baia Mare, Romania) ,  Ozon Emma Adriana (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania) ,  Udeanu Denisa (Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania) ,  Trifu Simona (Department of Clinical Neurosciences, “Carol Davila” University of Medicine and Pharmacy, 37 Dionisie Lupu St., 020021 Bucharest, Romania) ,  Nasui Bogdana Adriana (Faculty of Medicine, “Iuliu Hatieganu” University of Medicine and Pharmacy, 6 Louis Pasteur Street, 400349 Cluj-Napoca, Romania)
Material： Processes (Web)
Volume： 9  Issue： 1  Page： 176  Publication year： 2021 
JST Material Number： U7264A  ISSN： 2227-9717  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Alpha-lipoic acid (ALA, thioct...

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Thesaurus term： algorithm ,  optimization ,  simulation ,  dissolution ,  food ,  filler(pharmaceuticals) ,  multiplex ,  bioavailability ,  formulation ,  backup ,  pathological state ,  in vitro experiment ,  dietary supplement ,  *elution
Semi thesaurus term： 経口バイオアベイラビリティ , 【Automatic Indexing@JST】

Author keywords (7)： alpha-lipoic acid ,  tablets ,  dissolution rate ,  formulation effect ,  dissolution profiles ,  food supplements ,  quality target product profile

JST classification (3)： Basic biopharmacy  (GY01021U) ,  Drug therapy(=pharmacotherapy)for cardiovascular system diseases  (GJ05020M) ,  Clinical application of enzyme preparations and inhibitor preparations  (GW21020H)

Reference (91)：

• National Center for Biotechnology Information. PubChem Compound Summary for CID 6112, Lipoic Acid. Available online: https://pubchem.ncbi.nlm.nih.gov/compound/Lipoic-acid (accessed on 16 January 2021).
• Reed, L.J. Multienzyme complexes. Accounts Chem. Res. 1974, 7, 40-46.
• Navari-Izzo, F.; Quartacci, M.F.; Sgherri, C. Lipoic acid: A unique antioxidant in the detoxification of activated oxygen species. Plant Physiol. Biochem. 2002, 40, 463-470.
• Biewenga, G.P.; Haenen, G.R.; Bast, A. The pharmacology of the antioxidant lipoic acid. Gen. Pharmacol. Vasc. Syst. 1997, 29, 315-331.
• Bilska, A.; Wlodek, L. Lipoic acid-The drug of the future? Pharmacol. Rep. 2005, 57, 570-577.

Terms in the title (8)： α-リポ酸 ,  開発 ,  固体 ,  放出 ,  製剤 ,  溶出 ,  プロファイル ,  評価