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J-GLOBAL ID：202102241669271300   Reference number：21A0347906

Structural insight into microtubule stabilization and kinesin inhibition by Tau family MAPs

タウファミリーMAPによる微小管安定化とキネシン阻害への構造的洞察【JST・京大機械翻訳】

Author (17)： Shigematsu Hideki (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Shigematsu Hideki (RIKEN SPring-8 Center, Hyogo, Japan) ,  Imasaki Tsuyoshi (Division of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Imasaki Tsuyoshi (Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Saitama, Japan) ,  Doki Chihiro (Division of Applied Science and Engineering, Course of Biosystem, Graduate School of Muroran Institute of Technology, Muroran, Japan) ,  Sumi Takuya (Division of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan) ,  Aoki Mari (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Aoki Mari (RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan) ,  Uchikubo-Kamo Tomomi (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Uchikubo-Kamo Tomomi (RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan) ,  Sakamoto Ayako (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Sakamoto Ayako (RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan) ,  Tokuraku Kiyotaka (Division of Applied Science and Engineering, Course of Biosystem, Graduate School of Muroran Institute of Technology, Muroran, Japan) ,  Shirouzu Mikako (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Shirouzu Mikako (RIKEN Center for Biosystems Dynamics Research, Yokohama, Japan) ,  Nitta Ryo (RIKEN Center for Life Science Technologies, Yokohama, Japan) ,  Nitta Ryo (Division of Structural Medicine and Anatomy, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan)
Material： Journal of Cell Biology  (JCB)
Volume： 217  Issue： 12  Page： 4155-4163  Publication year： 2018 
JST Material Number： C0575A  ISSN： 0021-9525  CODEN： JCLBA3  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： The Tau family microtubule-ass...

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Thesaurus term： interface (surface) ,  Proteins ,  visualization ,  dimer ,  *microtubule ,  binding site ,  complex (substance) ,  Tubulin ,  microtubule-associated protein ,  Alternative Splicing ,  *Kinesin ,  C-terminal side ,  MAP4 ,  kinesin 1 ,  C terminal domain ,  molecular genetic phenomenon

JST classification (2)： Function of cell components  (EF03060C) ,  Cell physiology in general  (EF02010S)

Reference (45)：

• Aizawa. Molecular cloning of a ubiquitously distributed microtubule-associated protein with Mr 190,000. J. Biol. Chem. 1990, 265, 13849.
• Al-Bassam. MAP2 and tau bind longitudinally along the outer ridges of microtubule protofilaments. J. Cell Biol. 2002, 157, 1187. doi:10.1083/jcb.200201048
• Atherton. Conserved mechanisms of microtubule-stimulated ADP release, ATP binding, and force generation in transport kinesins. eLife. 2014, 3, e03680. doi:10.7554/eLife.03680
• Chau. The microtubule-associated protein tau cross-links to two distinct sites on each alpha and beta tubulin monomer via separate domains. Biochemistry. 1998, 37, 17692. doi:10.1021/bi9812118
• Chen. Projection domains of MAP2 and tau determine spacings between microtubules in dendrites and axons. Nature. 1992, 360, 674. doi:10.1038/360674a0

Terms in the title (6)： MAP ,  微小管 ,  安定化 ,  キネシン ,  阻害 ,  洞察