Art

J-GLOBAL ID：202102241980845860   Reference number：21A0349106

Hdac3 is an epigenetic inhibitor of the cytotoxicity program in CD8 T cells

Hdac3はCD8 T細胞における細胞毒性プログラムの後成的阻害剤である【JST・京大機械翻訳】

Author (18)： Tay Rong En (Department of Immunology, Harvard Medical School, Boston, MA) ,  Tay Rong En (Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA) ,  Olawoyin Olamide (Department of Immunology, Harvard Medical School, Boston, MA) ,  Olawoyin Olamide (Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA) ,  Cejas Paloma (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA) ,  Xie Yingtian (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA) ,  Meyer Clifford A. (Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA) ,  Ito Yoshinaga (Department of Immunology, Harvard Medical School, Boston, MA) ,  Ito Yoshinaga (Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA) ,  Weng Qing Yu (Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA) ,  Fisher David E. (Cutaneous Biology Research Center, Department of Dermatology, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA) ,  Long Henry W. (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA) ,  Brown Myles (Center for Functional Cancer Epigenetics, Dana-Farber Cancer Institute, Boston, MA) ,  Brown Myles (Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA) ,  Kim Hye-Jung (Department of Immunology, Harvard Medical School, Boston, MA) ,  Kim Hye-Jung (Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA) ,  Wucherpfennig Kai W. (Department of Immunology, Harvard Medical School, Boston, MA) ,  Wucherpfennig Kai W. (Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA)
Material： Journal of Experimental Medicine  (J Exp Med)
Volume： 217  Issue： 7  Page： Null  Publication year： 2020 
JST Material Number： A0937B  ISSN： 0022-1007  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Cytotoxic T cells play a key r...

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Thesaurus term： gene ,  tumor cell ,  Proteins ,  differentiation (biology) ,  *cytotoxicity ,  cytotoxic T cell ,  Cell Differentiation ,  transcription factor ,  *CD8 antigen ,  histone deacetylase ,  epigenetics ,  *CD8 positive T cell ,  transcription control ,  Adaptive Immunity ,  T cell activation ,  developmental physiology

JST classification (4)： Immunological reaction in general  (ED03010T) ,  Gene expression  (EC02040Q) ,  Infectious immunity  (ED03030P) ,  Cell physiology in general  (EF02010S)

Reference (57)：

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• Bennett. Targeting Epigenetics in Cancer. Annu. Rev. Pharmacol. Toxicol. 2018, 58, 187. doi:10.1146/annurev-pharmtox-010716-105106
• Best. Transcriptional insights into the CD8(+) T cell response to infection and memory T cell formation. Nat. Immunol. 2013, 14, 404. doi:10.1038/ni.2536
• Cannarile. Transcriptional regulator Id2 mediates CD8+ T cell immunity. Nat. Immunol. 2006, 7, 1317. doi:10.1038/ni1403
• Chang. Molecular regulation of effector and memory T cell differentiation. Nat. Immunol. 2014, 15, 1104. doi:10.1038/ni.3031

Terms in the title (5)： HDAC3 ,  CD8 ,  T細胞 ,  細胞毒性 ,  阻害剤