Art

J-GLOBAL ID：202102247751440546   Reference number：21A0059328

Causative and Susceptibility Genes for Alzheimer’s Disease: Our Trials and Latest Updates for Alzheimer’s Disease Genetic Research

アルツハイマー病の原因遺伝子と感受性遺伝子:我々の取り組みと国内外の最新事情

Author (4)： MIYASHITA AKINORI (新潟大 脳研 遺伝子機能解析学分野) ,  HARA NORIKAZU (新潟大 脳研 遺伝子機能解析学分野) ,  KASUGA KENSAKU (新潟大 脳研 遺伝子機能解析学分野) ,  IKEUCHI TAKESHI (新潟大 脳研 遺伝子機能解析学分野)
Material： 新潟医学会雑誌  (Niigata Medical Journal)
Volume： 134  Issue： 1  Page： 13-18  Publication year： Jan. 10, 2020 
JST Material Number： F0877A  ISSN： 0029-0440  CODEN： NIGZAY  Document type： Article
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *Alzheimer disease ,...
Semi thesaurus term： ApoE gene ,...

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JST classification (1)： Nervous system diseases  (GN03000O)

Reference (20)：

• Gatz M, Reynolds CA, Fratiglioni L, Johansson B, Mortimer JA, Berg S, Fiske A and Pedersen NL: Role of genes and environments for explaining Alzheimer disease. Arch Gen Psychiatry, 63: 168-174, 2006.
• Hardy J and Selkoe DJ: The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics. Science, 297: 353-356, 2002.
• Selkoe DJ and Hardy J: The amyloid hypothesis of Alzheimer’s disease at 25 years. EMBO Mol Med, 8: 595-608, 2016.
• Sevigny J, Chiao P, Bussière T, Weinreb PH, Williams L, Maier M, Dunstan R, Salloway S, Chen T, Ling Y, O’Gorman J, Qian F, Arastu M, Li M, Chollate S, Brennan MS, Quintero-Monzon O, Scannevin RH, Arnold HM, Engber T, Rhodes K, Ferrero J, Hang Y, Mikulskis A, Grimm J, Hock C, Nitsch RM and Sandrock A: The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease. Nature, 537: 50-56, 2016.
• https://www.eisai.co.jp/news/2019/pdf/news201979pdf.pdf

Terms in the title (3)： アルツハイマー ,  原因遺伝子 ,  感受性遺伝子