Art

J-GLOBAL ID：202102249483830014   Reference number：21A0023573

Proteolysis-targeting chimera (PROTAC) for targeted protein degradation and cancer therapy

標的蛋白質分解と癌治療のための蛋白質分解標的化キメラ(PROTAC)【JST・京大機械翻訳】

Author (3)： Li Xin (Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, USA) ,  Song Yongcheng (Department of Pharmacology and Chemical Biology, Baylor College of Medicine, Houston, USA) ,  Song Yongcheng (Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, USA)
Material： Journal of Hematology & Oncology (Web)
Volume： 13  Issue： 1  Page： 1-14  Publication year： 2020 
JST Material Number： U7517A  ISSN： 1756-8722  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Proteolysis-targeting chimera ...

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Thesaurus term： *protein ,  *chimera ,  clinical trial ,  *proteolysis ,  pharmacology ,  covalent bond ,  *targeting ,  proteasome ,  oncoprotein ,  ubiquitination
Semi thesaurus term： 悪性腫瘍 ,  *癌治療 ,  *標的蛋白質 ,  小分子阻害剤 ,  in vivo活性 , 【Automatic Indexing@JST】

Author keywords (4)： PROTAC ,  Targeted protein degradation ,  Cancer therapy ,  Hematological malignancies

JST classification (1)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A)

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Terms in the title (7)： 標的蛋白質 ,  分解 ,  癌治療 ,  蛋白質分解 ,  標的化 ,  キメラ ,  PROTAC