Art

J-GLOBAL ID：202102249639200891   Reference number：21A0217772

Effects of M-1, a Major Metabolite of Sarpogrelate, on 5-HT-Induced Constriction of Isolated Human Internal Thoracic Artery

分離したヒト内胸動脈の5-HT誘発収縮に対するサルポグレラートの主要な代謝物M-1の効果

Author (8)： Tanaka-Totoribe Naoko (Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Hidaka Muneaki (Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Gamoh Shuji (Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Yokota Atsuko (Department of Cardiovascular Surgery, Miyazaki City Medical Association Hospital) ,  Nakamura Eisaku (Department of Cardiovascular Surgery, Miyazaki Prefectural Miyazaki Hospital) ,  Kuwabara Masachika (Kuwabara Clinic) ,  Tsunezumi Jun (Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare) ,  Yamamoto Ryuichi (Graduate School of Clinical Pharmacy, Kyushu University of Health and Welfare)
Material： Biological and Pharmaceutical Bulletin (Web)
Volume： 43  Issue： 12  Page： 1979-1982(J-STAGE)  Publication year： 2020 
JST Material Number： U1402A  ISSN： 1347-5215  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human ,...
Semi thesaurus term： 血管収縮阻害作用

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Author keywords (12)： 5-hydroxytryptamine (5-HT) ,  sarpogrelate ,  vasoconstriction ,  internal thoracic artery ,  5-HT_2A receptor ,  5-HT_1B receptor ,  5-hydroxytryptamine (5-HT) ,  sarpogrelate ,  vasoconstriction ,  internal thoracic artery ,  5-HT_2A receptor ,  5-HT_1B receptor

JST classification (2)： Basic medicine on cardiovascular system  (GJ01020K) ,  Basic research of vasoactive drugs and hypotensive drugs  (GW07040J)

Substance index (4)： Serotonin ,  1-Naphthaleneacetic acid methyl ,  SB-224289 ,  Sarpogrelate

Reference (30)：

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• 3) Hoyer D, Clarke DE, Fozard JR, Hartig PR, Martin GR, Mylecharane EJ, Saxena PR, Humphrey PP. International Union of Pharmacology classification of receptors for 5-hydroxytryptamine (Serotonin). Pharmacol. Rev., 46, 157-203 (1994).
• 4) Gamoh S, Hisa H, Yamamoto R. 5-Hydroxytryptamine receptors as targets for drug therapies of vascular-related diseases. Biol. Pharm. Bull., 36, 1410-1415 (2013).
• 5) Vanhoutte PM. Endothelial dysfunction and vascular disease. Verh. K. Acad. Geneeskd. Belg., 60, 251-266 (1998).

Terms in the title (8)： ヒト ,  内胸動脈 ,  5-HT ,  誘発 ,  収縮 ,  サルポグレラート ,  代謝物 ,  M-1