Art

J-GLOBAL ID：202102249679126414   Reference number：21A0573198

Induction of G2/M Cell Cycle Arrest and Apoptosis by Genistein in Human Bladder Cancer T24 Cells through Inhibition of the ROS-Dependent PI3k/Akt Signal Transduction Pathway

ROS依存性PI3k/Aktシグナル伝達経路の阻害を介したヒト膀胱癌T24細胞におけるゲニステインによるG2/M細胞周期停止とアポトーシスの誘導【JST・京大機械翻訳】

Author (19)： Park Cheol (Department of Molecular Biology, College of Natural Sciences, Dong-eui University, Busan 47340, Korea) ,  Cha Hee-Jae (Department of Parasitology and Genetics, Kosin University College of Medicine, Busan 49267, Korea) ,  Lee Hyesook (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Lee Hyesook (Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea) ,  Hwang-Bo Hyun (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Hwang-Bo Hyun (Freshwater Bioresources Utilization Bureau, Nakdonggang National Institute of Biological Resources, Sangju 37242, Korea) ,  Ji Seon Yeong (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Ji Seon Yeong (Freshwater Bioresources Utilization Bureau, Nakdonggang National Institute of Biological Resources, Sangju 37242, Korea) ,  Kim Min Yeong (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Kim Min Yeong (Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea) ,  Hong Su Hyun (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Hong Su Hyun (Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea) ,  Jeong Jin-Woo (Freshwater Bioresources Utilization Bureau, Nakdonggang National Institute of Biological Resources, Sangju 37242, Korea) ,  Han Min Ho (National Marine Biodiversity Institute of Korea, Seocheon 33662, Korea) ,  Choi Sung Hyun (Department of System Management, Korea Lift College, Geochang 50141, Korea) ,  Jin Cheng-Yun (School of Pharmaceutical Sciences, Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou University, Henan 450001, China) ,  Kim Gi-Young (Department of Marine Life Sciences, Jeju National University, Jeju 63243, Korea) ,  Choi Yung Hyun (Anti-Aging Research Center, Dong-eui University, Busan 47340, Korea) ,  Choi Yung Hyun (Department of Biochemistry, Dong-eui University College of Korean Medicine, Busan 47227, Korea)
Material： Antioxidants (Web)
Volume： 8  Issue： 9  Page： 327  Publication year： 2019 
JST Material Number： U7134A  ISSN： 2076-3921  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： We examined the anti-cancer ef...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0573198&from=J-GLOBAL&jstjournalNo=U7134A") }}

Thesaurus term： gene ,  antitumor action ,  cytochrome c ,  human(primates) ,  mitochondria ,  *cell cycle ,  *cellular signal transduction ,  *apoptosis ,  caspase ,  cyclin-dependent kinase ,  nitrogen heterocyclic compound ,  quinolizidine alkaloid ,  bridged compound
Semi thesaurus term： *Akt/蛋白質キナーゼB ,  カスパーゼ3 ,  *T24細胞 ,  *細胞周期停止 , 【Automatic Indexing@JST】

Author keywords (5)： genistein ,  G2/M arrest ,  apoptosis ,  ROS ,  PI3K/Akt

JST classification (2)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Cell physiology in general  (EF02010S)

Substance index (1)： Genisteine

Reference (53)：

• Kumar, A.; Jaitak, V. Natural products as multidrug resistance modulators in cancer. Eur. J. Med. Chem. 2019, 176, 268-291.
• Fu, B.; Wang, N.; Tan, H.Y.; Li, S.; Cheung, F.; Feng, Y. Multi-component herbal products in the orevention and treatment of chemotherapy-associated toxicity and side effects: A review on experimental and clinical evidences. Front. Pharmacol. 2018, 9, 1394.
• Hernández-Ledesma, B.; Hsieh, C.C. Chemopreventive role of food-derived proteins and peptides: A review. Crit. Rev. Food Sci. Nutr. 2017, 57, 2358-2376.
• Tewari, D.; Rawat, P.; Singh, P.K. Adverse drug reactions of anticancer drugs derived from natural sources. Food Chem. Toxicol. 2019, 123, 522-535.
• Medema, R.H.; Macůrek, L. Checkpoint control and cancer. Oncogene 2012, 31, 2601-2613.

Terms in the title (14)： ROS ,  依存性 ,  PI3K ,  Akt ,  シグナル伝達経路 ,  阻害 ,  ヒト ,  膀胱癌 ,  T24細胞 ,  ゲニステイン ,  M細胞 ,  周期 ,  アポトーシス ,  誘導