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J-GLOBAL ID：202102250157439679   Reference number：21A0460577

Neuroinvasion of SARS-CoV-2 in human and mouse brain

ヒトおよびマウス脳におけるSARS-CoV-2の神経侵入【JST・京大機械翻訳】

Author (60)： Song Eric (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Zhang Ce (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Zhang Ce (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Israelow Benjamin (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Israelow Benjamin (Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT) ,  Lu-Culligan Alice (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Prado Alba Vieites (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Skriabine Sophie (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Lu Peiwen (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Weizman Orr-El (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Liu Feimei (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Liu Feimei (Department of Biomedical Engineering, Yale University, New Haven, CT) ,  Dai Yile (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Szigeti-Buck Klara (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Yasumoto Yuki (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Wang Guilin (Yale Center for Genome Analysis, West Haven, CT) ,  Castaldi Christopher (Yale Center for Genome Analysis, West Haven, CT) ,  Heltke Jaime (Yale Center for Genome Analysis, West Haven, CT) ,  Ng Evelyn (Yale Center for Genome Analysis, West Haven, CT) ,  Wheeler John (Yale Center for Genome Analysis, West Haven, CT) ,  Alfajaro Mia Madel (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Alfajaro Mia Madel (Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT) ,  Levavasseur Etienne (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Fontes Benjamin (Yale Environmental Health and Safety, Yale University, New Haven, CT) ,  Ravindra Neal G. (Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT) ,  Ravindra Neal G. (Department of Computer Science, Yale University, New Haven, CT) ,  Van Dijk David (Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale School of Medicine, New Haven, CT) ,  Van Dijk David (Department of Computer Science, Yale University, New Haven, CT) ,  Mane Shrikant (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Mane Shrikant (Yale Center for Genome Analysis, West Haven, CT) ,  Gunel Murat (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Gunel Murat (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Gunel Murat (Department of Neurosurgery, Yale School of Medicine, New Haven, CT) ,  Ring Aaron (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Kazmi Syed A. Jaffar (Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA) ,  Zhang Kai (Department of Laboratory Medicine, Geisinger Medical Center, Danville, PA) ,  Wilen Craig B. (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Wilen Craig B. (Department of Laboratory Medicine, Yale School of Medicine, New Haven, CT) ,  Horvath Tamas L. (Department of Comparative Medicine, Yale School of Medicine, New Haven, CT) ,  Plu Isabelle (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Plu Isabelle (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Haik Stephane (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Haik Stephane (Yale Environmental Health and Safety, Yale University, New Haven, CT) ,  Haik Stephane (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Haik Stephane (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Cellule nationale de reference des maladies de Creutzfeldt-Jakob, Paris, France) ,  Thomas Jean-Leon (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Thomas Jean-Leon (Department of Neurology, Yale School of Medicine, New Haven, CT) ,  Louvi Angeliki (Department of Neuroscience, Yale School of Medicine, New Haven, CT) ,  Louvi Angeliki (Department of Neurosurgery, Yale School of Medicine, New Haven, CT) ,  Farhadian Shelli F. (Department of Internal Medicine, Section of Infectious Diseases, Yale School of Medicine, New Haven, CT) ,  Farhadian Shelli F. (Department of Neurology, Yale School of Medicine, New Haven, CT) ,  Huttner Anita (Department of Pathology, Yale School of Medicine, New Haven, CT) ,  Seilhean Danielle (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Seilhean Danielle (Assistance Publique Hopitaux de Paris, Hopital Pitie-Salpetriere, Departement de Neuropathologie, Paris, France) ,  Renier Nicolas (Sorbonne Universite, INSERM U1127, French National Centre for Scientific Research, Joint Research Unit 7225, Paris Brain Institute, Institut du Cerveau et de la Moelle Epiniere, Paris, France) ,  Bilguvar Kaya (Department of Genetics, Yale School of Medicine, New Haven, CT) ,  Bilguvar Kaya (Yale Center for Genome Analysis, West Haven, CT) ,  Iwasaki Akiko (Department of Immunobiology, Yale School of Medicine, New Haven, CT) ,  Iwasaki Akiko (Department of Molecular, Cellular, and Developmental Biology, Yale School of Medicine, New Haven, CT) ,  Iwasaki Akiko (Howard Hughes Medical Institute, Chevy Chase, MD)
Material： Journal of Experimental Medicine  (J Exp Med)
Volume： 218  Issue： 3  Page： Null  Publication year： 2021 
JST Material Number： A0937B  ISSN： 0022-1007  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Although COVID-19 is considere...

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Thesaurus term： neuron ,  antibody ,  respiratory tract disease ,  cerebrospinal fluid ,  Central Nervous System ,  *human ,  cell infiltration ,  Organoid ,  Angiotensin-converting Enzyme 2 ,  overexpression ,  body fluid
Semi thesaurus term： 神経浸潤 , 【Automatic Indexing@JST】

JST classification (1)： Physiology and pathogenicity of virus infection  (EG04042Y)

Reference (43)：

• Amin. Building Models of Brain Disorders with Three-Dimensional Organoids. Neuron. 2018, 100, 389. doi:10.1016/j.neuron.2018.10.007
• Baig. Potential neuroinvasive pathways of SARS-CoV-2: Deciphering the spectrum of neurological deficit seen in coronavirus disease-2019 (COVID-19). J. Med. Virol. 2020, 92, 1845. doi:10.1002/jmv.26105
• Blanco-Melo. Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19. Cell. 2020, 181, 1036. doi:10.1016/j.cell.2020.04.026
• Bullen. Infectability of human BrainSphere neurons suggests neurotropism of SARS-CoV-2. ALTEX. 2020, 37, 665. doi:10.14573/altex.2006111
• Cakir. Engineering of human brain organoids with a functional vascular-like system. Nat. Methods. 2019, 16, 1169. doi:10.1038/s41592-019-0586-5

Terms in the title (6)： ヒト ,  マウス ,  脳 ,  SARS-CoV-2 ,  神経 ,  侵入