Art

J-GLOBAL ID：202102250416748988   Reference number：21A1993666

Neurodegenerative diseases: a hotbed for splicing defects and the potential therapies

神経変性疾患:スプライシング欠損のホットベッドと潜在的治療【JST・京大機械翻訳】

Author (10)： Li Dunhui (Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia) ,  Li Dunhui (Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Australia) ,  McIntosh Craig Stewart (Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia) ,  McIntosh Craig Stewart (Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Australia) ,  Mastaglia Frank Louis (Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia) ,  Mastaglia Frank Louis (Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Australia) ,  Wilton Steve Donald (Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia) ,  Wilton Steve Donald (Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Australia) ,  Aung-Htut May Thandar (Centre for Molecular Medicine and Innovative Therapeutics, Health Futures Institute, Murdoch University, Perth, Australia) ,  Aung-Htut May Thandar (Perron Institute for Neurological and Translational Science, Centre for Neuromuscular and Neurological Disorders, The University of Western Australia, Perth, Australia)
Material： Translational Neurodegeneration (Web)
Volume： 10  Issue： 1  Page： 1-18  Publication year： 2021 
JST Material Number： U7346A  ISSN： 2047-9158  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Precursor messenger RNA (pre-m...

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Thesaurus term： plasticity ,  neuron ,  *mRNA ,  heredity ,  synapse ,  homeostasis ,  eucaryote ,  intron ,  Alzheimer disease ,  Parkinson's disease ,  alternative splicing ,  proteome
Semi thesaurus term： *神経変性疾患 ,  アンチセンスオリゴヌクレオチド ,  非翻訳領域 , 【Automatic Indexing@JST】

Author keywords (8)： Neurodegenerative diseases ,  Parkinson’s disease ,  Alzheimer’s disease ,  Alternative splicing ,  Splicing defects ,  Antisense oligonucleotides ,  Splice-switching ,  Disease-modifying treatment

JST classification (1)： Gene expression  (EC02040Q)

Reference (192)：

• Adv Drug Del Rev.; Antisense oligonucleotides in therapy for neurodegenerative disorders; MM Evers, LJ Toonen, WM Roon-Mom; 87; 2015; 90-103; 10.1016/j.addr.2015.03.008; citation_id=CR1
• Nat Med.; Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases; JL Guo, VM Lee; 20; 2; 2014; 130-138; 10.1038/nm.3457; citation_id=CR2
• Nat Rev Neurosci.; Molecular genetics: unmasking polyglutamine triggers in neurodegenerative disease; JF Gusella, ME MacDonald; 1; 2; 2000; 109-115; 10.1038/35039051; citation_id=CR3
• Neurobiol Aging; Alternative splicing of mRNA in the molecular pathology of neurodegenerative diseases; JD Mills, M Janitz; 33; 5; 2012; 1012.e11-1012.e24; 10.1016/j.neurobiolaging.2011.10.030; citation_id=CR4
• Science.; Toxic proteins in neurodegenerative disease; JP Taylor, J Hardy, KH Fischbeck; 296; 5575; 2002; 1991-1995; 10.1126/science.1067122; citation_id=CR5

Terms in the title (5)： 神経変性疾患 ,  スプライシング ,  欠損 ,  ベッド ,  治療