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J-GLOBAL ID：202102252408115488   Reference number：21A1992345

miR-19a/b-3p promotes inflammation during cerebral ischemia/reperfusion injury via SIRT1/FoxO3/SPHK1 pathway

miR-19a/b-3pはSIRT1/FoxO3/SPHK1経路を介して脳虚血/再灌流傷害時の炎症を促進する【JST・京大機械翻訳】

Author (5)： Zhou Feng (Research Center of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China) ,  Zhou Feng (Department of Neurology, First People’s Hospital of Foshan, Foshan, People’s Republic of China) ,  Wang Yu-Kai (Department of Neurology, First People’s Hospital of Foshan, Foshan, People’s Republic of China) ,  Zhang Cheng-Guo (Department of Neurology, First People’s Hospital of Foshan, Foshan, People’s Republic of China) ,  Wu Bing-Yi (Research Center of Clinical Medicine, Nanfang Hospital, Southern Medical University, Guangzhou, People’s Republic of China)
Material： Journal of Neuroinflammation (Web)
Volume： 18  Issue： 1  Page： 1-13  Publication year： 2021 
JST Material Number： U7329A  ISSN： 1742-2094  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Stroke affects 3-4% of adults ...

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Thesaurus term： mRNA ,  *inflammation ,  *ischemia ,  promoter(genetics) ,  cerebral apoplexy ,  targeting ,  *cerebral ischemia ,  reperfusion ,  TNF alpha ,  apoptosis ,  TUNEL method
Semi thesaurus term： インターロイキン1β ,  p65 ,  虚血再潅流 ,  炎症反応 , 【Automatic Indexing@JST】

Author keywords (6)： Ischemia ,  miR-19a/b-3p ,  SIRT1 ,  FoxO3 ,  SPHK1 ,  Inflammation

JST classification (2)： Basic neurology  (GN01020W) ,  Biological function  (EB03040U)

Reference (41)：

• Guzik A, Bushnell C. Stroke epidemiology and risk factor management. Continuum (Minneap Minn). 2017;23(1, Cerebrovascular Disease):15-39.
• Methodist Debakey Cardiovasc J.; Modern medical management of acute ischemic stroke; LB Goldstein; 10; 2; 2014; 99-104; 10.14797/mdcj-10-2-99; citation_id=CR2
• J Neuroinflammation.; Neuroinflammation: friend and foe for ischemic stroke; RL Jayaraj, S Azimullah, R Beiram, FY Jalal, GA Rosenberg; 16; 1; 2019; 142; 10.1186/s12974-019-1516-2; citation_id=CR3
• Angiology.; Link between oxidative stress and acute brain ischemia; D Radak, I Resanovic, ER Isenovic; 65; 8; 2014; 667-676; 10.1177/0003319713506516; citation_id=CR4
• Neurotherapeutics.; Inflammation and stroke: an overview; J Anrather, C Iadecola; 13; 4; 2016; 661-670; 10.1007/s13311-016-0483-x; citation_id=CR5

Terms in the title (7)： SIRT1 ,  FoxO3 ,  経路 ,  脳虚血 ,  再灌流傷害 ,  炎症 ,  促進