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J-GLOBAL ID：202102253139671609   Reference number：21A0328545

A newly developed age estimation method based on CpG methylation of teeth-derived DNA using real-time methylation-specific PCR

リアルタイムメチル化特異的PCRを用いた歯由来DNAのCpGメチル化に基づく新たに開発した年齢推定法

Author (7)： Kondo Masahiro (Department of Legal Medicine, Nihon University School of Dentistry) ,  Aboshi Hirofumi (Department of Legal Medicine, Nihon University School of Dentistry) ,  Yoshikawa Masaaki (Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine) ,  Ogata Ayano (Department of Legal Medicine, Nihon University School of Dentistry) ,  Murayama Ryosuke (Department of Legal Medicine, Nihon University School of Dentistry) ,  Takei Masami (Division of Hematology and Rheumatology, Department of Medicine, Nihon University School of Medicine) ,  Aizawa Shin (Division of Anatomical Science, Department of Functional Morphology, Nihon University School of Medicine)
Material： Journal of Oral Science  (J Oral Sci)
Volume： 63  Issue： 1  Page： 54-58(J-STAGE)  Publication year： 2021 
JST Material Number： Z0759A  ISSN： 1343-4934  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： human(primates) ,...
Semi thesaurus term： dead body ,...

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Author keywords (6)： age estimation ,  bisulfite conversion ,  CpG islands ,  DNA methylation ,  ELOVL2 ,  forensic age

JST classification (1)： Clinical dentistry(= odontology)in general  (GT01030Z)

Reference (37)：

• 1. Vidaki A, Daniel B, Court DS (2013) Forensic DNA methylation profiling- potential opportunities and challenges. Forensic Sci Int Genet 7, 499-507.
• 2. Kader F, Ghai M (2015) DNA methylation and application in forensic sciences. Forensic Sci Int 249, 255-265.
• 3. Johnson TE (2006) Recent results: biomarkers of aging. Exp Gerontol 41, 1243-1246.
• 4. Alkass K, Buchholz BA, Ohtani S, Yamamoto T, Druid H, Spalding KL (2010) Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis. Mol Cell Proteomics 9, 1022-1030.
• 5. Deaton A, Brid A (2011) CpG islands and the regulation of transcription. Genes Dev 25, 1010-1022.

Terms in the title (8)： リアルタイム ,  メチル化 ,  PCR ,  歯 ,  DNA ,  CpGメチル化 ,  開発 ,  年齢推定