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J-GLOBAL ID：202102255535734987   Reference number：21A0204314

Single intratracheal administration of cross-linked water-soluble acrylic acid polymer causes acute alveolo-interstitial inflammation and the subsequent fibrotic formation possibly via the TGF-β1 pathway in the lung of rats

架橋水溶性アクリル酸ポリマーの単回気管内投与は,ラットの肺におけるTGF-β1経路を介した急性肺胞間質性炎症とその後の線維化形成を引き起こす【JST・京大機械翻訳】

Author (10)： Suka Machi (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Kido Takamasa (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Yoshioka Wataru (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Hachisuka Eri (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Okoshi Hiroto (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Yamauchi Takashi (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan) ,  Hano Hiroshi (Department of Pathology, The Jikei University School of Medicine, Japan) ,  Okano Takashi (Laboratory of Chemistry, The Jikei University School of Medicine, Japan) ,  Yokoyama Masayuki (Medical Engineering Laboratory, Research Center for Medical Sciences, The Jikei University School of Medicine, Japan) ,  Yanagisawa Hiroyuki (Department of Public Health and Environmental Medicine, The Jikei University School of Medicine, Japan)
Material： Toxicology
Volume： 448  Page： Null  Publication year： 2021 
JST Material Number： D0444C  ISSN： 0300-483X  CODEN： TXCYAC  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In a Japanese chemical factory...

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Thesaurus term： *polymer ,  *inflammation ,  collagen ,  *pulmonary alveolus ,  *rat ,  monomer ,  worker ,  myeloperoxidase ,  macrophage ,  fibronectin ,  lung disease ,  matrix metalloproteinase ,  bronchoalveolar lavage fluid ,  aliphatic carboxylic acid ,  vinyl compound ,  unsaturated carboxylic acid
Semi thesaurus term： 急性肺炎 , 【Automatic Indexing@JST】

Author keywords (4)： Cross-linked water-soluble acrylic acid polymer ,  Intratracheal instillation ,  Pulmonary fibrosis ,  Rats

JST classification (2)： Toxicity of metals and metal compounds  (GZ02022V) ,  Basic medicine on respiratory system  (GI01020H)

Substance index (1)： Acrylic acid

Terms in the title (11)： 架橋 ,  水溶性 ,  アクリル酸 ,  ポリマー ,  気管内投与 ,  ラット ,  肺 ,  経路 ,  肺胞 ,  間質性炎症 ,  線維化