Art

J-GLOBAL ID：202102256423065376   Reference number：21A0155473

Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells

NRF2とその標的遺伝子の持続的高発現は,ヒト気管支上皮細胞の亜ヒ酸塩誘発悪性形質転換と関連する【JST・京大機械翻訳】

Author (10)： Kong Qi (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China) ,  Deng Hanyi (Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China) ,  Li Chunchun (Changzhou Wujin District Center for Disease Control and Prevention, Changzhou 213164, Jiangsu, China) ,  Wang Xiaojuan (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China) ,  Shimoda Yasuyo (Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Chiba 274-8555, Japan) ,  Tao Shasha (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China) ,  Kato Koichi (Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Chiba 274-8555, Japan) ,  Zhang Jie (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China) ,  Yamanaka Kenzo (Laboratory of Environmental Toxicology and Carcinogenesis, School of Pharmacy, Nihon University, Chiba 274-8555, Japan) ,  An Yan (Department of Toxicology, School of Public Health, Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China)
Material： Science of the Total Environment  (Sci Total Environ)
Volume： 756  Page： Null  Publication year： 2021 
JST Material Number： C0501B  ISSN： 0048-9697  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： In arsenic toxicity, activatio...

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Thesaurus term： arsenic ,  *arsenite ,  protein ,  human(primates) ,  phenotype ,  cell proliferation ,  complex(substance) ,  cell cycle ,  gene expression ,  apoptosis ,  caspase ,  gene silencing
Semi thesaurus term： サイクリンE ,  S期 ,  *標的遺伝子 , 【Automatic Indexing@JST】

Author keywords (6)： Arsenite ,  Cellular proliferation ,  Cellular apoptosis ,  NRF2 ,  NQO1 ,  Human bronchial epithelial cell

JST classification (2)： Influence on humans  (EE05050C) ,  Other pollutants  (SB05040W)

Terms in the title (8)： NRF2 ,  標的遺伝子 ,  発現 ,  ヒト ,  気管支上皮細胞 ,  亜ヒ酸塩 ,  誘発 ,  悪性形質転換