Art

J-GLOBAL ID：202102257304337547   Reference number：21A0264732

Protective effect of ISO-1 with inhibition of RIPK3 up-regulation and neutrophilic accumulation on acetaminophen-induced liver injury in mice

マウスにおけるアセトアミノフェン誘発肝障害に対するRIPK3アップレギュレーションと好中球蓄積の阻害によるISO-1の保護作用【JST・京大機械翻訳】

Author (5)： Ohkawara Tatsuya (Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan) ,  Okubo Naoto (Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan) ,  Maehara Osamu (Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan) ,  Nishihira Jun (Department of Medical Management and Informatics, Faculty of Business Administration and Information Science, Hokkaido Information University, Nishinopporo, 59-2, Ebetsu, 069-8585, Japan) ,  Takeda Hiroshi (Pathophysiology and Therapeutics, Hokkaido University Faculty of Pharmaceutical Sciences, kita-12, nishi-6, kita-ku Sapporo, 060-8638, Japan)
Material： Toxicology Letters  (Toxicol Lett)
Volume： 339  Page： 51-59  Publication year： 2021 
JST Material Number： E0034B  ISSN： 0378-4274  CODEN： TOLED5  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Overdose use of acetaminophen ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0264732&from=J-GLOBAL&jstjournalNo=E0034B") }}

Thesaurus term： interaction ,  alanine aminotransferase ,  dyeing ,  serum concentration ,  protein kinase ,  myeloperoxidase ,  Cell Count ,  macrophage ,  *Neutrophils ,  *hepatic dysfunction ,  *Up-Regulation ,  TUNEL method ,  Acute liver failure ,  Liver damage ,  peroxidase ,  fatty acid ,  aromatic amine ,  phenolic compound ,  carboxamide ,  aminoalcohol

Author keywords (5)： Acetaminophen ,  ISO-1 ,  Macrophage migration inhibitory factor ,  Liver injury ,  RIPK3

JST classification (3)： Basic research of drugs acting on digestive system  (GW09010Q) ,  Basic medicine on digestive system  (GH01020E) ,  Basic research of antipyretic analgesics  (GW03040H)

Substance index (1)： Acetaminophen

Terms in the title (11)： マウス ,  アセトアミノフェン ,  誘発 ,  肝障害 ,  RIPK3 ,  アップレギュレーション ,  好中球 ,  蓄積 ,  阻害 ,  ISO ,  保護作用