Art

J-GLOBAL ID：202102257472374770   Reference number：21A1766850

IL-6 Promotes the Proliferation and Immunosuppressive Function of Myeloid-Derived Suppressor Cells via the MAPK Signaling Pathway in Bladder Cancer

IL-6は膀胱癌においてMAPKシグナル伝達経路を介して骨髄由来サプレッサー細胞の増殖と免疫抑制機能を促進する【JST・京大機械翻訳】

Author (13)： Zheng Zhong (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Zheng Xinyi (Department of Pharmacy, Huashan Hospital, Fudan University, Shanghai, China) ,  Zhu Yiwen (School of Rehabilitation Science, Shanghai University of Traditional Chinese Medicine, Shanghai, China) ,  Yao Zhixian (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Zhao Weiguang (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Zhu Youjia (The Second School of Medicine, Wenzhou Medical University, Wenzhou, China) ,  Sun Feng (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Mu Xingyu (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Wang Yong (Department of Urology, Shanghai Jiangqiao Hospital, Jiading Branch, Shanghai General Hospital, Shanghai, China) ,  He Wanqing (Student Innovation Center, Shanghai Jiao Tong University, Shanghai, China) ,  Liu Zhihong (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Wu Ke (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China) ,  Zheng Junhua (Department of Urology, Shanghai General Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China)
Material： BioMed Research International (Web)  (BioMed Res Int (Web))
Volume： 2021  Page： Null  Publication year： 2021 
JST Material Number： U7008A  ISSN： 2314-6133  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Muscle-invasive bladder cancer...

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Thesaurus term： immersional wetting ,  tumor cell ,  cell proliferation ,  *immunosuppression ,  T cell ,  characterization ,  interleukin ,  *bladder tumor ,  *interleukin 6 ,  MAP kinase ,  coculture ,  growth stimulation
Semi thesaurus term： 増殖能 ,  CD4陽性細胞 ,  CD8陽性細胞 , 【Automatic Indexing@JST】

JST classification (2)： Cell physiology in general  (EF02010S) ,  Infectious diseases,parasitics diseases in general.  (GD01010H)

Reference (41)：

• N. Mahdavifar, M. Ghoncheh, R. Pakzad, Z. Momenimovahed, H. Salehiniya, "Epidemiology, incidence and mortality of bladder cancer and their relationship with the development index in the world," Asian Pacific Journal of Cancer Prevention, vol. 17, no. 1, pp. 381-386, 2016.
• L. Klotz, M. A. Brausi, "World Urologic Oncology Federation Bladder Cancer Prevention Program: a global initiative," Urologic Oncology, vol. 33, no. 1, pp. 25-29, 2015.
• S. Lei, H. Xu, N. Chen, H. Pan, W. Xie, Y. He, J. Jin, "MKP-1 overexpression is associated with chemoresistance in bladder cancer via the MAPK pathway," Oncology Letters, vol. 20, no. 2, pp. 1743-1751, 2020.
• P. L. Crispen, S. Kusmartsev, "Mechanisms of immune evasion in bladder cancer," Cancer Immunology, Immunotherapy, vol. 69, no. 1, pp. 3-14, 2020.
• A. K. Schneider, M. F. Chevalier, L. Derré, "The multifaceted immune regulation of bladder cancer," Nature Reviews. Urology, vol. 16, no. 10, pp. 613-630, 2019.

Terms in the title (8)： IL-6 ,  膀胱癌 ,  MAPK ,  シグナル伝達経路 ,  骨髄由来サプレッサー細胞 ,  増殖 ,  免疫抑制 ,  促進