Art

J-GLOBAL ID：202102261170110754   Reference number：21A0295113

Protrudin-deficient mice manifest depression-like behavior with abnormalities in activity, attention, and cued fear-conditioning

プロトルジン欠乏マウスは活性,注意およびキュード恐怖条件付けにおける異常を伴ううつ病様行動を示す【JST・京大機械翻訳】

Author (8)： Shirane Michiko (Department of Molecular Biology, Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya, Japan) ,  Shoji Hirotaka (Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan) ,  Hashimoto Yutaka (Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan) ,  Katagiri Hiroyuki (Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo, Japan) ,  Kobayashi Shizuka (Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo, Japan) ,  Manabe Toshiya (Division of Neuronal Network, Department of Basic Medical Sciences, Institute of Medical Science, University of Tokyo, Tokyo, Japan) ,  Miyakawa Tsuyoshi (Division of Systems Medical Science, Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Japan) ,  Nakayama Keiichi I. (Department of Molecular and Cellular Biology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan)
Material： Molecular Brain (Web)
Volume： 13  Issue： 1  Page： 1-18  Publication year： 2020 
JST Material Number： U7335A  ISSN： 1756-6606  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Protrudin is a protein that re...

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Thesaurus term： nervous system ,  gene ,  endoplasmic reticulum ,  protein ,  secondary battery ,  *depression(disease) ,  fear ,  knockout mouse
Semi thesaurus term： 遺伝性痙性対麻痺 ,  多動 ,  神経変性 ,  異常行動 ,  神経発生 ,  エンドフェノタイプ , 【Automatic Indexing@JST】

Author keywords (5)： Protrudin ,  Knockout mouse ,  Behavior ,  Hyperactivity ,  Depression

JST classification (2)： Basic neurology  (GN01020W) ,  Central nervous system  (EJ12030F)

Reference (38)：

• Science; Protrudin induces neurite formation by directional membrane trafficking; M Shirane, KI Nakayama; 314; 2006; 818-821; 10.1126/science.1134027; citation_id=CR1
• J Biol Chem; Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein; S Saita, M Shirane, T Natume, S Iemura, KI Nakayama; 284; 2009; 13766-13777; 10.1074/jbc.M807938200; citation_id=CR2
• Mol Biol Cell; Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation; F Matsuzaki, M Shirane, M Matsumoto, KI Nakayama; 22; 2011; 4602-4620; 10.1091/mbc.e11-01-0068; citation_id=CR3
• Genes Cells; Identification and characterization of a neuron-specific isoform of protrudin; T Ohnishi, M Shirane, Y Hashimoto, S Saita, KI Nakayama; 19; 2014; 97-111; 10.1111/gtc.12109; citation_id=CR4
• Sci Rep; SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth; T Ohnishi, M Shirane, KI Nakayama; 7; 2017; 41130; 10.1038/srep41130; citation_id=CR5

Terms in the title (8)： 欠乏 ,  マウス ,  活性 ,  注意 ,  キュー ,  恐怖条件付け ,  うつ病 ,  行動