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J-GLOBAL ID：202102261386909323   Reference number：21A0217288

Gram-negative bacterial lipopolysaccharide and antimicrobial LL-37 enhance ICAM-1 expression and NF-κB activation in senescent endothelial cells

グラム陰性菌LPSおよび抗菌ペプチドLL-37による老化血管内皮細胞の炎症性応答の増強

Author (2)： SUZUKI KAORI (順天堂大学大学院医学研究科生化学・生体防御学) ,  NAGAOKA ISAO (順天堂大学大学院医学研究科生化学・生体防御学)
Material： エンドトキシン・自然免疫研究(Web)
Volume： 23  Page： 47-53(J-STAGE)  Publication year： 2020 
JST Material Number： U1552A  ISSN： 2434-1177  Document type： Proceedings
Article type： 解説  Country of issue： Japan (JPN)  Language： JAPANESE (JA)

Thesaurus term： *lipopolysaccharide ,...
Semi thesaurus term： HUVEC cell ,...

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Author keywords (4)： LL-37 ,  cellular senescence ,  senescence-associated secretory phenotype (SASP) ,  NF-κB

JST classification (4)： Cardiovascular system diseases  (GJ03000C) ,  Basic medicine on cardiovascular system  (GJ01020K) ,  Microorganism biochemistry  (EG03020N) ,  Physiology and pathogenicity of microbial infection  (EG03053T)

Reference (15)：

• 1) Hayflick L, Moorhead PS : The serial cultivation of human diploid cell strains. Exp Cell Res 25 : 585-621, 1961
• 2) Childs BG, Durik M, Baker DJ, et al. : Cellular senescence in aging and age-related disease : from mechanisms to therapy. Nat Med 21 : 1424-1435, 2015
• 3) Yanaka M, Honma T, Sato K, et al. : Increased monocytic adhesion by senescence in human umbilical vein endothelial cells. Biosci Biotechnol Biochem 75 : 1098-1103, 2011
• 4) Salminen A, Kauppinen A, Kaarniranta K : Emerging role of NF-κB signaling in the induction of senescence-associated secretory phenotype (SASP). Cell Signal 24 : 835-845, 2012
• 5) Shembade N, Harhaj EW : Regulation of NF-κB signaling by the A20 deubiquitinase. Cell Mol Immunol 9 : 123-130, 2012

Terms in the title (7)： グラム陰性菌 ,  LPS ,  抗菌ペプチド ,  老化 ,  血管内皮細胞 ,  炎症性応答 ,  増強