Art

J-GLOBAL ID：202102262290911876   Reference number：21A2114086

Allosteric GABAA Receptor Modulators-A Review on the Most Recent Heterocyclic Chemotypes and Their Synthetic Accessibility

アロステリックGABA_A受容体調節因子-最も最近の複素環ケモタイプとそれらの合成アクセシビリティに関するレビュー【JST・京大機械翻訳】

Author (7)： Alanis Blanca Angelica Vega (Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria) ,  Iorio Maria Teresa (Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria) ,  Silva Luca L. (Department of Anesthesiology and Intensive Care Medicine, Charite-Universitaetsmedizin, Chariteplatz 1, 10117 Berlin, Germany) ,  Bampali Konstantina (Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria) ,  Ernst Margot (Department of Molecular Neurosciences, Center for Brain Research, Medical University of Vienna, Spitalgasse 4, 1090 Vienna, Austria) ,  Schnuerch Michael (Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria) ,  Mihovilovic Marko D. (Institute of Applied Synthetic Chemistry, TU Wien, Getreidemarkt 9/193, 1060 Vienna, Austria)
Material： Molecules (Web)
Volume： 25  Issue： 4  Page： 999  Publication year： 2020 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： GABAA receptor modulators are ...

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Thesaurus term： modulator ,  nitrogen heterocyclic compound ,  *receptor ,  clinical trial ,  *heterocyclic compound ,  accessibility ,  GABAA receptor
Semi thesaurus term： *ケモタイプ ,  *調節因子 ,  標的蛋白質 , 【Automatic Indexing@JST】

Author keywords (5)： GABA_A modulators ,  allosteric modulators ,  heterocyclic modulators ,  heterocyclic synthesis ,  nitrogen heterocycles

JST classification (2)： Receptors on cell membrane  (EF04030C) ,  Computer simulation  (JE11000H)

Reference (165)：

• Jampilek, J. Heterocycles in Medicinal Chemistry. Molecules 2019, 24, 3839.
• Volonterio, A.; Zanda, M. Multicomponent, One-Pot Sequential Synthesis of 1,3,5- and 1,3,5,5-Substituted Barbiturates. J. Org. Chem. 2008, 73, 7486-7497.
• Goodwin, N.C.; Morrison, J.P.; Fuerst, D.E.; Hadi, T. Biocatalysis in Medicinal Chemistry: Challenges to Access and Drivers for Adoption. ACS Med. Chem. Lett. 2019, 10, 1363-1366.
• Bogdan, A.R.; Organ, M.G. Flow Chemistry as a Drug Discovery Tool: A Medicinal Chemistry Perspective. In Flow Chemistry for the Synthesis of Heterocycles; Sharma, U.K., Van der Eycken, E.V., Eds.; Springer International Publishing: Cham, Switzerland, 2018; pp. 319-341.
• Bogdos, M.K.; Pinard, E.; Murphy, J.A. Applications of organocatalysed visible-light photoredox reactions for medicinal chemistry. Beilstein J. Org. Chem. 2018, 14, 2035-2064.

Terms in the title (6)： 受容体 ,  調節因子 ,  複素環 ,  ケモタイプ ,  アクセシビリティ ,  レビュー