Art

J-GLOBAL ID：202102265290830835   Reference number：21A0029958

PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

ラパマイシン治療によるPKCダウンレギュレーションはミトコンドリア疾患を軽減する【JST・京大機械翻訳】

Author (18)： Martin-Perez Miguel (Department of Genome Sciences, University of Washington, Seattle, WA, USA) ,  Martin-Perez Miguel (Institute for Research in Biomedicine (IRB Barcelona), The Barcelona Institute of Science and Technology (BIST), Barcelona, Spain) ,  Martin-Perez Miguel (Department of Cell Biology, Physiology and Immunology, University of Barcelona, Barcelona, Spain) ,  Grillo Anthony S. (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Ito Takashi K. (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Ito Takashi K. (RIKEN Center for Sustainable Resource Science, Saitama, Japan) ,  Valente Anthony S. (Department of Genome Sciences, University of Washington, Seattle, WA, USA) ,  Han Jeehae (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Entwisle Samuel W. (Department of Genome Sciences, University of Washington, Seattle, WA, USA) ,  Entwisle Samuel W. (Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA) ,  Entwisle Samuel W. (Department of Genetics, Harvard Medical School, Boston, MA, USA) ,  Huang Heather Z. (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Kim Dayae (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Yajima Masanao (Department of Mathematics and Statistics, Boston University, Boston, MA, USA) ,  Kaeberlein Matt (Department of Pathology, University of Washington, Seattle, WA, USA) ,  Kaeberlein Matt (Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA) ,  Villen Judit (Department of Genome Sciences, University of Washington, Seattle, WA, USA) ,  Villen Judit (Molecular and Cellular Biology Graduate Program, University of Washington, Seattle, WA, USA)
Material： Nature Metabolism
Volume： 2  Issue： 12  Page： 1472-1481  Publication year： 2020 
JST Material Number： W6371A  ISSN： 2522-5812  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Leigh syndrome is a ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0029958&from=J-GLOBAL&jstjournalNo=W6371A") }}

Thesaurus term： Inflammation ,  metabolic error ,  complex (substance) ,  neuropathy ,  *Down-Regulation ,  protein kinase C ,  *mitochondrial disease ,  proteome ,  Mitochondrial Proteins ,  isoform ,  mitochondrial function ,  mouse model ,  Signal Transduction ,  *hereditary disease ,  *congenital disease ,  ether ,  macrocyclic compound ,  lactam ,  lactone ,  enzyme inhibitor ,  hemiacetal ,  alicyclic alcohol ,  secondary alcohol ,  hydroxy ketone
Semi thesaurus term： cellular signal transduction ,  治療標的 , 【Automatic Indexing@JST】

JST classification (1)： Cell physiology in general  (EF02010S)

Substance index (1)： Sirolimus

Terms in the title (5)： ラパマイシン ,  治療 ,  PKC ,  ダウンレギュレーション ,  ミトコンドリア疾患