Art

J-GLOBAL ID：202102265837924449   Reference number：21A0829463

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

腫瘍微小環境における低酸素駆動免疫回避【JST・京大機械翻訳】

Author (3)： Vito Alyssa (Department of Biochemistry and Biomedical Sciences, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada) ,  El-Sayes Nader (Department of Biochemistry and Biomedical Sciences, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada) ,  Mossman Karen (Department of Pathology and Molecular Medicine, McMaster Immunology Research Centre, McMaster University, Hamilton, ON L8S 4K1, Canada)
Material： Cells (Web)
Volume： 9  Issue： 4  Page： 992  Publication year： 2020 
JST Material Number： U7155A  ISSN： 2073-4409  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The tumor microenvironment is ...

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Thesaurus term： oxygen consumption ,  *tumor ,  anoxia ,  *oxygen deficiency ,  immunosuppression ,  cardiovascular system ,  immunotherapy ,  clone ,  ecosystem ,  cytokine ,  cell death
Semi thesaurus term： 予後不良 ,  *免疫回避 ,  治療標的 ,  *腫瘍内微小環境 , 【Automatic Indexing@JST】

Author keywords (4)： hypoxia ,  tumor microenvironment ,  immunogenic cell death ,  therapeutics

JST classification (1)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (149)：

• Multhoff, G.; Vaupel, P. Hypoxia compromises anti-cancer immune responses. In Advances in Experimental Medicine and Biology; Springer: Berlin, Germany, 2020; Volume 1232, pp. 131-143.
• Krock, B.L.; Skuli, N.; Simon, M.C. Hypoxia-Induced Angiogenesis: Good and Evil. Genes Cancer 2011, 2, 1117-1133.
• Chen, L.; Endler, A.; Shibasaki, F. Hypoxia and angiogenesis: Regulation of hypoxia-inducible factors via novel binding factors. Exp. Mol. Med. 2009, 41, 849-857.
• Engel, C.; Brügmann, G.; Lambing, S.; Mühlenbeck, L.H.; Marx, S.; Hagen, C.; Horv, D.; Goldeck, M.; Ludwig, J.; Herzne, A.M.; et al. RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation. Cancer Immunol. Res. 2017, 5, 455-467.
• Zhao, T.; Ren, H.; Jia, L.; Chen, J.; Xin, W.; Yan, F.; Li, J.; Wang, X.; Gao, S.; Qian, D.; et al. Inhibition of HIF-1α by PX-478 enhances the anti-tumor effect of gemcitabine by inducing immunogenic cell death in pancreatic ductal adenocarcinoma. Oncotarget 2015, 6, 2250-2262.

Terms in the title (3)： 腫瘍微小環境 ,  低酸素 ,  免疫回避