Art

J-GLOBAL ID：202102268821872737   Reference number：21A0722924

Long-Term Systemic Expression of a Novel PD-1 Blocking Nanobody from an AAV Vector Provides Antitumor Activity without Toxicity

AAVベクターからの新規PD-1ブロッキングナノボディの長期全身発現は毒性のない抗腫瘍活性を提供する【JST・京大機械翻訳】

Author (17)： Silva-Pilipich Noelia (Division of Gene Therapy and Regulation of Gene Expression, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Silva-Pilipich Noelia (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Silva-Pilipich Noelia (Catedra de Inmunologia, DEPBIO, Facultad de Quimica, Instituto de Higiene, UDELAR, 11600 Montevideo, Uruguay) ,  Martisova Eva (Division of Gene Therapy and Regulation of Gene Expression, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Martisova Eva (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Ballesteros-Briones Maria Cristina (Division of Gene Therapy and Regulation of Gene Expression, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Ballesteros-Briones Maria Cristina (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Hervas-Stubbs Sandra (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Hervas-Stubbs Sandra (Division of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Hervas-Stubbs Sandra (CIBERehd, Instituto de Salud Carlos III, 28029 Madrid, Spain) ,  Casares Noelia (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Casares Noelia (Division of Immunology and Immunotherapy, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Gonzalez-Sapienza Gualberto (Catedra de Inmunologia, DEPBIO, Facultad de Quimica, Instituto de Higiene, UDELAR, 11600 Montevideo, Uruguay) ,  Smerdou Cristian (Division of Gene Therapy and Regulation of Gene Expression, Cima Universidad de Navarra, 31008 Pamplona, Spain) ,  Smerdou Cristian (Instituto de Investigacion Sanitaria de Navarra (IdISNA), 31008 Pamplona, Spain) ,  Vanrell Lucia (Catedra de Inmunologia, DEPBIO, Facultad de Quimica, Instituto de Higiene, UDELAR, 11600 Montevideo, Uruguay) ,  Vanrell Lucia (Facultad de Ingenieria, Universidad ORT, 11100 Montevideo, Uruguay)
Material： Biomedicines (Web)
Volume： 8  Issue： 12  Page： 562  Publication year： 2020 
JST Material Number： U7146A  ISSN： 2227-9059  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Immune checkpoint blockade usi...

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Thesaurus term： interaction ,  *antitumor action ,  *tumor ,  intravenous administration ,  human(primates) ,  side effect ,  Rodentia ,  promoter(genetics) ,  clone ,  *vector(genetics) ,  monoclonal antibody ,  in vitro experiment ,  tumorigenesis
Semi thesaurus term： *単一ドメイン抗体 ,  *プログラム細胞死1受容体 , 【Automatic Indexing@JST】

Author keywords (8)： nanobody ,  VHH ,  PD-1 ,  PD-L1 ,  AAV vector ,  cancer ,  gene therapy ,  immunotherapy

JST classification (5)： Research and development  (GU01040N) ,  Immunotherapy for tumors  (GE03035B) ,  Immunological reaction in general  (ED03010T) ,  Clinical application of antitumor(=antineoplastic)drugs  (GW16020L) ,  Cell physiology in general  (EF02010S)

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Terms in the title (9)： AAVベクター ,  PD-1 ,  ブロッキング ,  ナノボディ ,  長期 ,  全身 ,  発現 ,  毒性 ,  抗腫瘍活性