Art

J-GLOBAL ID：202102269049686927   Reference number：21A0099535

Epigenome-wide DNA methylation analysis of small cell lung cancer cell lines suggests potential chemotherapy targets

小細胞肺癌細胞株のエピゲノムワイドDNAメチル化解析は潜在的化学療法標的を示唆する【JST・京大機械翻訳】

Author (13)： Krushkal Julia (Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, USA) ,  Silvers Thomas (Molecular Pharmacology Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA) ,  Reinhold William C. (Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA) ,  Sonkin Dmitriy (Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, USA) ,  Vural Suleyman (Biometric Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, NIH, Rockville, USA) ,  Connelly John (Molecular Pharmacology Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA) ,  Varma Sudhir (Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA) ,  Meltzer Paul S. (Genetics Branch, Center for Cancer Research, National Cancer Institute, Bethesda, USA) ,  Kunkel Mark (Drug Synthesis and Chemistry Branch, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, USA) ,  Rapisarda Annamaria (Molecular Pharmacology Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA) ,  Evans David (Molecular Pharmacology Group, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, USA) ,  Pommier Yves (Developmental Therapeutics Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, USA) ,  Teicher Beverly A. (Molecular Pharmacology Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, Bethesda, USA)
Material： Clinical Epigenetics (Web)
Volume： 12  Issue： 1  Page： 1-28  Publication year： 2020 
JST Material Number： U7316A  ISSN： 1868-7083  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Small cell lung cancer (SCLC) ...

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Thesaurus term： aurora ,  *methylation ,  *DNA ,  antitumor drug ,  human(primates) ,  microtubule ,  *drug therapy ,  cytosol ,  gene expression ,  in vitro experiment ,  DNA lesion ,  *small cell lung cancer
Semi thesaurus term： *DNAメチル化 ,  BCL-2 ,  mRNA発現 , 【Automatic Indexing@JST】

Author keywords (5)： DNA methylation ,  Small cell lung cancer ,  Gene expression ,  Epigenetic regulation ,  Chemotherapy

JST classification (2)： Tumors(=neoplasms)of respiratory system  (GI04000G) ,  Genetic variation  (EC01030Y)

Reference (86)：

• J Clin Oncol.; Changing epidemiology of small-cell lung cancer in the United States over the last 30 years: analysis of the surveillance, epidemiologic, and end results database; R Govindan, N Page, D Morgensztern, W Read, R Tierney, A Vlahiotis; 24; 2006; 4539-4544; citation_id=CR1
• Nat Rev Cancer.; Molecular subtypes of small cell lung cancer: a synthesis of human and mouse model data; CM Rudin, JT Poirier, LA Byers, C Dive, A Dowlati, J George; 19; 2019; 289-297; citation_id=CR2
• Nat Rev Cancer.; Small-cell lung cancer: what we know, what we need to know and the path forward; AF Gazdar, PA Bunn, JD Minna; 17; 2017; 725-737; citation_id=CR3
• National Cancer Institute list of drugs approves for lung cancer. Available from: https://www.cancer.gov/about-cancer/treatment/drugs/lung. Accessed: 20 Sept 2019.
• Nature.; Comprehensive genomic profiles of small cell lung cancer; J George, JS Lim, SJ Jang, Y Cun, L Ozretic, G Kong; 524; 2015; 47-53; citation_id=CR5

Terms in the title (7)： 小細胞肺癌 ,  細胞株 ,  エピゲノム ,  DNAメチル化 ,  解析 ,  化学療法 ,  標的