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J-GLOBAL ID：202102272573455573   Reference number：21A3071494

Alzheimer’s Disease Pathogenesis: Role of Autophagy and Mitophagy Focusing in Microglia

アルツハイマー病の病因:ミクログリアにおけるオートファジーとマイトファジー集束の役割【JST・京大機械翻訳】

Author (13)： Eshraghi Mehdi (Center for Motor Neuron Biology and Disease, Columbia University, New York, NY 10032, USA) ,  Eshraghi Mehdi (Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA) ,  Adlimoghaddam Aida (St. Boniface Hospital Albrechtsen Research Centre, Division of Neurodegenerative Disorders, Winnipeg, MB R2H2A6, Canada) ,  Mahmoodzadeh Amir (Medical Biology Research Center, Health Technology Institute, Kermanshah University of Medical Sciences, Kermanshah 6734667149, Iran) ,  Sharifzad Farzaneh (Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada) ,  Yasavoli-Sharahi Hamed (Department of Cellular and Molecular Medicine, Faculty of Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada) ,  Lorzadeh Shahrokh (Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada) ,  Albensi Benedict C. (St. Boniface Hospital Albrechtsen Research Centre, Division of Neurodegenerative Disorders, Winnipeg, MB R2H2A6, Canada) ,  Albensi Benedict C. (Department of Pharmacology & Therapeutics, University of Manitoba, Winnipeg, MB R3T 2N2, Canada) ,  Ghavami Saeid (Department of Human Anatomy and Cell Science, Rady Faculty of Health Sciences, Max Rady College of Medicine, University of Manitoba, Winnipeg, MB R3E 0J9, Canada) ,  Ghavami Saeid (Research Institute of Oncology and Hematology, Cancer Care Manitoba-University of Manitoba, Winnipeg, MB R3E 0V9, Canada) ,  Ghavami Saeid (Biology of Breathing Theme, Children Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB R3E 0V9, Canada) ,  Ghavami Saeid (Faculty of Medicine, Katowice School of Technology, 40-555 Katowice, Poland)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 22  Issue： 7  Page： 3330  Publication year： 2021 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Alzheimer’s disease (AD) is a ...

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Thesaurus term： *focusing ,  interaction ,  inflammation ,  mitochondria ,  *Alzheimer disease ,  pathological state ,  *pathogenesis ,  *microglia ,  amyloid plaque ,  *autophagy
Semi thesaurus term： 無力症 ,  炎症性細胞 ,  治療標的 ,  *マイトファジー ,  神経系炎症 , 【Automatic Indexing@JST】

Author keywords (8)： mitochondria ,  inflammation ,  autophagy ,  mitophagy ,  microglia ,  Alzheimer’s ,  neurodegeneration ,  neuroinflammation

JST classification (1)： Basic neurology  (GN01020W)

Reference (381)：

• Liu, P.-P.; Xie, Y.; Meng, X.-Y.; Kang, J.-S. History and progress of hypotheses and clinical trials for Alzheimer’s disease. Signal. Transduct. Target. Ther. 2019, 4, 29.
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• Glabe, C.C. Amyloid accumulation and pathogensis of Alzheimer’s disease: Significance of monomeric, oligomeric and fibrillar Abeta. Sub-Cell. Biochem. 2005, 38, 167-177.
• Hardy, J.; Selkoe, D.J. The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics. Science. 2002, 297, 353-356.

Terms in the title (7)： アルツハイマー ,  病因 ,  ミクログリア ,  オートファジー ,  マイトファジー ,  集束 ,  役割