Art

J-GLOBAL ID：202102273395574718   Reference number：21A0777597

Identification of Celastrol as a Novel YAP-TEAD Inhibitor for Cancer Therapy by High Throughput Screening with Ultrasensitive YAP/TAZ-TEAD Biosensors

超高感度YAP/TAZ-TEADバイオセンサを用いたハイスループットスクリーニングによる癌治療のための新規YAP-TEAD阻害剤としてのセラストロールの同定【JST・京大機械翻訳】

Author (9)： Nouri Kazem (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Azad Taha (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Ling Min (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Rensburg Helena J. Janse van (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Pipchuk Alexander (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Shen He (Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA) ,  Hao Yawei (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada) ,  Zhang Jianmin (Department of Cancer Genetics and Genomics, Roswell Park Cancer Institute, Buffalo, NY 14263, USA) ,  Yang Xiaolong (Department of Pathology and Molecular Medicine, Queen’s University, Kingston, ON K7L 3N6, Canada)
Material： Cancers (Web)
Volume： 11  Issue： 10  Page： 1596  Publication year： 2019 
JST Material Number： U7153A  ISSN： 2072-6694  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The Hippo pathway has emerged ...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A0777597&from=J-GLOBAL&jstjournalNo=U7153A") }}

Thesaurus term： interaction ,  luminance ,  bacterium ,  molecular compound ,  tumor cell ,  biological activity ,  *biosensor ,  transcription factor ,  in vitro experiment ,  fusion protein ,  cell migration
Semi thesaurus term： *ハイスループットスクリーニングアッセイ ,  蛋白質間相互作用 ,  *癌治療 ,  生細胞 , 【Automatic Indexing@JST】

Author keywords (5)： NanoLuc ,  biosensor ,  Hippo pathway ,  high throughput screening ,  cancer

JST classification (4)： Biological function  (EB03040U) ,  Cell physiology in general  (EF02010S) ,  Carcinogenic mechanisms and factors  (GE02020C) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Reference (41)：

• Janse van Rensburg, H.J.; Yang, X. The roles of the Hippo pathway in cancer metastasis. Cell. Signal. 2016, 28, 1761-1772.
• Yang, X.; Xu, T. Molecular mechanism of size control in development and human diseases. Cell Res. 2011, 21, 715-729.
• Moya, I.M.; Halder, G. Hippo-YAP/TAZ signalling in organ regeneration and regenerative medicine. Nat. Rev. Mol. Cell Biol. 2019, 20, 211-226.
• Yu, F.X.; Zhao, B.; Guan, K.L. Hippo Pathway in Organ Size Control, Tissue Homeostasis, and Cancer. Cell 2015, 163, 811-828.
• Zygulska, A.L.; Krzemieniecki, K.; Pierzchalski, P. Hippo pathway-brief overview of its relevance in cancer. J. Physiol. Pharmacol. 2017, 68, 311-335.

Terms in the title (10)： 高感度 ,  YAP ,  TAZ ,  TEAD ,  バイオセンサ ,  ハイスループットスクリーニング ,  癌治療 ,  阻害剤 ,  セラストロール ,  同定