Art

J-GLOBAL ID：202102274531539854   Reference number：21A2090856

Spray Congealing: An Emerging Technology to Prepare Solid Dispersions with Enhanced Oral Bioavailability of Poorly Water Soluble Drugs

スプレーコンゲアリング:難水溶性薬物の経口バイオアベイラビリティ強化による固体分散調製のための新しい技術【JST・京大機械翻訳】

Author (3)： Bertoni Serena ,  Albertini Beatrice ,  Passerini Nadia
Material： Molecules (Web)
Volume： 24  Issue： 19  Page： 3471  Publication year： 2019 
JST Material Number： U7014A  ISSN： 1420-3049  CODEN： MOLEFW  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： The low and variable oral bioa...

Register(free) or Log In to access     To see more with JDream III (charged).   {{ this.onShowAbsJLink("http://jdream3.com/lp/jglobal/index.html?docNo=21A2090856&from=J-GLOBAL&jstjournalNo=U7014A") }}

Thesaurus term： dissolution ,  solubility(ratio) ,  fine particle ,  setting(solidification) ,  gel ,  hydrophilicity ,  solution velocity ,  polyethylene oxide ,  filler(pharmaceuticals) ,  *bioavailability ,  formulation
Semi thesaurus term： 物理化学的性質 ,  固体分散体 ,  *難溶性薬物 ,  *経口バイオアベイラビリティ , 【Automatic Indexing@JST】

Author keywords (8)： spray chilling ,  spray cooling ,  microparticles ,  solubility enhancement ,  dissolution rate ,  polyethylene glycol ,  poloxamer ,  Gelucire

JST classification (2)： Medical materials  (GA05040H) ,  Basic biopharmacy  (GY01021U)

Reference (93)：

• Chella, N.; Tadikonda, R. Melt dispersion granules: Formulation and evaluation to improve oral delivery of poorly soluble drugs-A case study with valsartan. Drug Dev. Ind. Pharm. 2015, 41, 888-897.
• Morishita, M.; Peppas, N.A. Advances in oral drug delivery: Improved bioavailability of poorly absorbed drugs by tissue and cellular optimization. Adv. Drug Deliv. Rev. 2012, 64, 479.
• Kawabata, Y.; Wada, K.; Nakatani, M.; Yamada, S.; Onoue, S. Formulation design for poorly water-soluble drugs based on biopharmaceutics classification system: Basic approaches and practical applications. Int. J. Pharm. 2011, 420, 1-10.
• Lipinski, C.A. Drug-like properties and the causes of poor solubility and poor permeability. J. Pharmacol. Toxicol. Methods 2000, 44, 235-249.
• FDA. Guidance for Industry, Waiver of In Vivo Bioavailability and Bioequivalence Studies for Immediate-Release Solid Oral Dosage Forms based on a Biopharmaceutics Classification System; FDA: Silver Spring, MD, USA, 2000.

Terms in the title (5)： 難水溶性薬物 ,  経口バイオアベイラビリティ ,  強化 ,  固体 ,  調製