Art

J-GLOBAL ID：202102276467063710   Reference number：21A0370040

Simple Synthesis of a Heterocyclophane Exhibiting Anti-c-Met Activity by Acting as a Hatch Blocking Access to the Active Site**

活性部位単糖類への孵化ブロッキングアクセスとして作用する抗c-Met活性を示すヘテロシクロファンの簡易合成【JST・京大機械翻訳】

Author (13)： Takimoto Tatsuya (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Sasaki Hideaki (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Tsue Hirohito (Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan) ,  Takahashi Hiroki (Graduate School of Human and Environmental Studies, Kyoto University, Yoshida Nihonmatsu-cho, Sakyo-ku, Kyoto, 606-8501, Japan) ,  MacKerell Alexander D. Jr. (Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, 20 Penn Street, Baltimore, Maryland, 21201, USA) ,  Nakamura Ayumi (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Nakano Katsuya (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Okazaki Eori (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Betsuyaku Tatsuki (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Tachibana Ryosuke (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Hioki Kazuhito (Faculty of Pharmaceutical Sciences, Kobe Gakuin University, Minatojima, chuo-ku, Kobe, 650-8586, Japan) ,  Yoluk Ozge (Department of Pharmaceutical Sciences, School of Pharmacy, University of Maryland Baltimore, 20 Penn Street, Baltimore, Maryland, 21201, USA) ,  Jo Sunhwan (SilcsBio LLC, 20 Penn Street, Baltimore, Maryland, 21201, USA)
Material： Chemistry - European Journal  (Chem Eur J)
Volume： 27  Issue： 5  Page： 1648-1654  Publication year： 2021 
JST Material Number： W0744A  ISSN： 0947-6539  CODEN： CEUJED  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： A simple approach to the synth...

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Thesaurus term： *monosaccharide ,  epithelium ,  *active site ,  amino group ,  protein kinase ,  acylation ,  *hatching ,  *cyclophane ,  functionalization ,  mesenchyme ,  aliphatic alcohol
Semi thesaurus term： カルバマート ,  リンカ ,  還流 , 【Automatic Indexing@JST】

Author keywords (5)： computational chemistry ,  cyclophanes ,  drug design ,  inhibitors ,  synthetic design

JST classification (1)： Cyclophanes,catenanes,rhotaxanes,knots  (CF06120M)

Substance index (2)： 4,4'-Bithiazole ,  Methanol

Terms in the title (8)： 活性部位 ,  単糖類 ,  孵化 ,  ブロッキング ,  アクセス ,  c-met ,  活性 ,  簡易