Art

J-GLOBAL ID：202102276483804844   Reference number：21A0294024

The nSMase2/Smpd3 gene modulates the severity of muscular dystrophy and the emotional stress response in mdx mice

nSMase2/Smpd3遺伝子はmdxマウスにおける筋ジストロフィーの重症度と情動ストレス応答を調節する【JST・京大機械翻訳】

Author (19)： Matsuzaka Yasunari (Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Matsuzaka Yasunari (Medical Molecular Informatics, Meiji Pharmaceutical University, Kiyose, Japan) ,  Tanihata Jun (Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Tanihata Jun (Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan) ,  Ooshima Yoshiko (Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Yamada Daisuke (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Yamada Daisuke (Laboratory of Pharmacology, Department of Pharmacy, Faculty of Pharmaceutical Sciences, Tokyo University of Science, Noda, Japan) ,  Sekiguchi Masayuki (Department of Degenerative Neurological Diseases, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Miyatake Shouta (Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Aoki Yoshitsugu (Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Terumitsu Mika (Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Yashiro Ryu (Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Komaki Hirofumi (Department of Child Neurology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Ishiyama Akihiko (Department of Child Neurology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Oya Yasushi (Department of Neurology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Inoue Yukiko U. (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Inoue Takayoshi (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Takeda Shin'ichi (Department of Molecular Therapy, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan) ,  Hashido Kazuo (Administrative Section of Radiation Protection, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Kodaira, Japan)
Material： BMC Medicine (Web)
Volume： 18  Issue： 1  Page： 1-22  Publication year： 2020 
JST Material Number： U7435A  ISSN： 1741-7015  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Duchenne muscular dystrophy (D...

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Thesaurus term： Hydrolysis ,  *gene ,  sphingomyelin ,  Proteins ,  Eumetopias jubata ,  *muscular dystrophy ,  *emotional stress ,  pathological state ,  Apoptosis ,  lipid raft ,  Cell Survival ,  *stress response ,  Endomembrane system
Semi thesaurus term： 治療標的 ,  *ジストロフィー , 【Automatic Indexing@JST】

Author keywords (10)： Duchenne muscular dystrophy ,  Neutral sphingomyelinase 2/sphingomyelin phosphodiesterase 3 ,  CRISPR-Cas9 ,  Inflammatory cytokine ,  Monocytes/macrophages ,  Membrane permeability ,  Muscle performance ,  microRNA ,  Brain-derived neurotrophic factor ,  Anxiety behavior

JST classification (2)： Basic neurology  (GN01020W) ,  Muscles  (EJ10020G)

Reference (62)：

• Clin Chest Med; Muscular dystrophies; JC Carter, DW Sheehan, A Prochoroff, DJ Birnkrant; 39; 2018; 377-389; 10.1016/j.ccm.2018.01.004; citation_id=CR1
• Curr Treat Options Neurol; Current and emerging therapies for Duchenne muscular dystrophy; M Crone, JK Mah; 20; 2018; 31; 10.1007/s11940-018-0513-6; citation_id=CR2
• Heydemann A. Skeletal muscle metabolism in Duchenne and Becker muscular dystrophy-implications for therapies. Nutrients. 2018;10. https://doi.org/10.3390/nu10060796.
• Smith LR, Barton ER. Regulation of fibrosis in muscular dystrophy. Matrix Biol. 2018;68-9:602-15. doi:https://doi.org/10.1016/j.matbio.2018.01.014.
• Thakur SS, Swiderski K, Ryall JG, Lynch GS. Therapeutic potential of heat shock protein induction for muscular dystrophy and other muscle wasting conditions. Philos Trans R Soc Lond B Biol Sci. 2018;373. https://doi.org/10.1098/rstb.2016.0528.

Terms in the title (7)： 遺伝子 ,  MDXマウス ,  筋ジストロフィー ,  重症度 ,  情動ストレス ,  応答 ,  調節