Art

J-GLOBAL ID：202102277357869718   Reference number：21A0091954

Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis

血液および気管支肺胞洗浄液中の内因性分泌RAGEの減少は特発性肺線維症における予後不良と関連する【JST・京大機械翻訳】

Author (13)： Yamaguchi Kakuhiro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Iwamoto Hiroshi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Mazur Witold (Heart and Lung Centre, Division of Pulmonary Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland) ,  Miura Shinichiro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Sakamoto Shinjiro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Horimasu Yasushi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Masuda Takeshi (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Miyamoto Shintaro (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Nakashima Taku (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Ohshimo Shinichiro (Department of Emergency and Critical Care Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Fujitaka Kazunori (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hamada Hironobu (Department of Physical Analysis and Therapeutic Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hattori Noboru (Department of Molecular and Internal Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan)
Material： Respiratory Research (Web)
Volume： 21  Issue： 1  Page： 1-8  Publication year： 2020 
JST Material Number： U7545A  ISSN： 1465-993X  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The endogenous secretory recep...

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Thesaurus term： interaction ,  Carbon Monoxide ,  gene ,  Serum ,  anti-inflammatory action ,  receptor ,  serum concentration ,  *Prognosis ,  Alternative Splicing ,  biomarker ,  *bronchoalveolar lavage fluid ,  *endogenous ,  isoform ,  Lung mechanics ,  molecular genetic phenomenon
Semi thesaurus term： *特発性肺線維症 , 【Automatic Indexing@JST】

Author keywords (5)： esRAGE ,  IPF ,  BALF ,  Serum ,  Biomarker

JST classification (4)： Receptors on cell membrane  (EF04030C) ,  Urogenital diseases  (GM03000L) ,  Biological function  (EB03040U) ,  Immunologic diseases,allergic diseases in general.  (GD04010C)

Reference (36)：

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• J Biol Chem; Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-kappaB require the cytoplasmic domain of the receptor but different downstream signaling pathways; HJ Huttunen, C Fages, H Rauvala; 274; 1999; 19919-19924; 10.1074/jbc.274.28.19919; citation_id=CR2
• Cell Tissue Res; Promotion of cell adherence and spreading: a novel function of RAGE, the highly selective differentiation marker of human alveolar epithelial type I cells; N Demling, C Ehrhardt, M Kasper, M Laue, L Knels, EP Rieber; 323; 2006; 475-488; 10.1007/s00441-005-0069-0; citation_id=CR3
• Am J Respir Cell Mol Biol; Identification of genes differentially expressed in rat alveolar type I cells; K Dahlin, EM Mager, L Allen, Z Tigue, L Goodglick, M Wadehra; 31; 2004; 309-316; 10.1165/rcmb.2003-0423OC; citation_id=CR4
• J Biomed Biotechnol; The receptor for advanced glycation end products (RAGE) and the lung; ST Buckley, C Ehrhardt; 2010; 2010; 917108; 10.1155/2010/917108; citation_id=CR5

Terms in the title (7)： 血液 ,  気管支肺胞洗浄液 ,  内因性 ,  分泌 ,  RAGE ,  特発性肺線維症 ,  予後不良