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J-GLOBAL ID：202102287893508485   Reference number：21A0295104

Touchscreen-based location discrimination and paired associate learning tasks detect cognitive impairment at an early stage in an App knock-in mouse model of Alzheimer’s disease

タッチスクリーンに基づく位置識別と対連合学習課題は,アルツハイマー病のノックインマウス・モデルでの早期における認知障害を検出する【JST・京大機械翻訳】

Author (14)： Saifullah Md. Ali Bin (Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Komine Okiru (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Dong Yutao (Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Dong Yutao (Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan) ,  Fukumoto Kazuya (Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Sobue Akira (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Endo Fumito (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Saito Takashi (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Saito Takashi (Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan) ,  Saito Takashi (Department of Neurocognitive Science, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan) ,  Saido Takaomi C. (Laboratory for Proteolytic Neuroscience, RIKEN Center for Brain Science, Wako, Japan) ,  Yamanaka Koji (Department of Neuroscience and Pathobiology, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Mizoguchi Hiroyuki (Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Aichi, Japan) ,  Mizoguchi Hiroyuki (Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan)
Material： Molecular Brain (Web)
Volume： 13  Issue： 1  Page： 1-13  Publication year： 2020 
JST Material Number： U7335A  ISSN： 1756-6606  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Alzheimer’s disease (AD) is a ...

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Thesaurus term： task performance ,  Phenotype ,  secondary battery ,  deposition ,  *touch screen ,  screening (inspection) ,  neurofibril ,  *Alzheimer Disease ,  pathological state ,  amyloid beta-protein ,  Neurodegenerative Diseases ,  Disease Progression ,  Models, Animal ,  *Cognition Disorders ,  *knock-in mouse ,  Amyloid ,  glycoprotein ,  animal protein

Author keywords (5)： Alzheimer’s disease ,  Touchscreen ,  Amyloid beta ,  Early stage ,  App-KI

JST classification (1)： Basic neurology  (GN01020W)

Reference (57)：

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• Prog Neuropsychopharmacol Biol Psychiatry; Long-term effects of rivastigmine in moderately severe Alzheimer's disease: does early initiation of therapy offer sustained benefits?; PM Doraiswamy, KR Krishnan, R Anand, H Sohn, J Danyluk, RD Hartman; 26; 2002; 705-712; 10.1016/S0278-5846(01)00326-8; citation_id=CR5

Terms in the title (8)： タッチスクリーン ,  位置識別 ,  学習課題 ,  アルツハイマー ,  ノックインマウス ,  モデル ,  早期 ,  認知障害