Art

J-GLOBAL ID：202102289056626831   Reference number：21A1905678

The role of IGF2BP2, an m6A reader gene, in human metabolic diseases and cancers

ヒト代謝疾患および癌におけるm6Aリーダー遺伝子IGF2BP2の役割【JST・京大機械翻訳】

Author (4)： Wang Jinyan (Department of Oncology, Zhangjiagang First People’s Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, China) ,  Wang Jinyan (The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China) ,  Chen Lijuan (Department of Gynecology, Zhangjiagang First People’s Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, People’s Republic of China) ,  Qiang Ping (Department of Gynecology, Zhangjiagang First People’s Hospital, Zhangjiagang Affiliated Hospital of Soochow University, Zhangjiagang, People’s Republic of China)
Material： Cancer Cell International (Web)
Volume： 21  Issue： 1  Page： 1-11  Publication year： 2021 
JST Material Number： U7315A  ISSN： 1475-2867  Document type： Article
Article type： 文献レビュー  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The human insulin-like growth ...

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Thesaurus term： RNA ,  mRNA ,  *gene ,  fatty liver ,  diabetes mellitus ,  human(primates) ,  prognosis ,  type 2 diabetes mellitus ,  RNA binding protein
Semi thesaurus term： マイクロRNA ,  非翻訳RNA ,  結合蛋白質 ,  予後因子 ,  転写後調節 ,  細胞代謝 , 【Automatic Indexing@JST】

Author keywords (5)： IGF2BP2 ,  m6A ,  Metabolic disease ,  Cancers ,  Biological function

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Gene expression  (EC02040Q)

Reference (116)：

• Mol Cell Biol; A family of insulin-like growth factor II mRNA-binding proteins represses translation in late development; J Nielsen, J Christiansen, J Lykke-Andersen, AH Johnsen, UM Wewer, FC Nielsen; 19; 1999; 1262-1270; 10.1128/MCB.19.2.1262; citation_id=CR1
• Stem Cells Int; IGF2 mRNA-binding protein 2: biological function and putative role in type 2 diabetes; J Christiansen, AM Kolte, T Hansen, FC Nielsen; 43; 2009; 187-195; citation_id=CR2
• Genes Dev; mTOR phosphorylates IMP2 to promote IGF2 mRNA translation by internal ribosomal entry; N Dai, J Rapley, M Angel, MF Yanik, MD Blower, J Avruch; 25; 2011; 1159-1172; 10.1101/gad.2042311; citation_id=CR3
• Trends Endocrinol Metab; The diverse functions of IMP2/IGF2BP2 in metabolism; N Dai; 31; 2020; 670-679; 10.1016/j.tem.2020.05.007; citation_id=CR4
• Stem Cells Intern; The roles of insulin-like growth factor 2 mRNA-binding protein 2 in cancer and cancer stem cells; J Cao, Q Mu; 2018; 2018; 4217259; citation_id=CR5

Terms in the title (6)： ヒト ,  代謝疾患 ,  癌 ,  リーダー ,  遺伝子 ,  役割