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J-GLOBAL ID：202102290837286147   Reference number：21A0295896

Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility

ダウン症候群細胞接着分子様1(DSCAML1)はGABA系と発作感受性を結びつける【JST・京大機械翻訳】

Author (34)： Hayase Yoneko (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Amano Shigeru (Graduate School of Medicine Faculty of Health Science, Department of Laboratory Medicine, Kyoto University, Kyoto, Japan) ,  Hashizume Koichi (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Tominaga Takashi (Laboratory for Neural Circuit System, Institute of Neuroscience, Tokushima Bunri University, Sanuki, Japan) ,  Miyamoto Hiroyuki (International Research Center for Neurointelligence (IRCN), The University of Tokyo, Tokyo, Japan) ,  Kanno Yukie (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Ueno-Inoue Yukiko (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Inoue Takayoshi (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Yamada Mayumi (Research Center for Dynamic Living Systems, Graduate School of Biostudies, Kyoto University, Kyoto, Japan) ,  Ogata Shigehiro (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Balan Shabeesh (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan) ,  Hayashi Ken (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Miura Yoshiki (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Tokudome Kentaro (Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan) ,  Ohno Yukihiro (Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Takatsuki, Japan) ,  Nishijo Takuma (Department of Pharmacology, Jikei University School of Medicine, Tokyo, Japan) ,  Momiyama Toshihiko (Department of Pharmacology, Jikei University School of Medicine, Tokyo, Japan) ,  Yanagawa Yuchio (Genetic and Behavioral Neuroscience, Gunma University Graduate School of Medicine, Maebashi, Japan) ,  Takizawa Akiko (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Mashimo Tomoji (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Mashimo Tomoji (Laboratory Animal Research Center, Institute of Medical Science, The University of Tokyo, Tokyo, Japan) ,  Serikawa Tadao (Institute of Laboratory Animals, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Sekine Akihiro (Omics-Based Medicine, Center for Preventive Medical Science, Chiba University, Chiba, Japan) ,  Nakagawa Eiji (Department of Pediatric Neurology, National Center Hospital, NCNP, Tokyo, Japan) ,  Takeshita Eri (Department of Pediatric Neurology, National Center Hospital, NCNP, Tokyo, Japan) ,  Yoshikawa Takeo (Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan) ,  Waga Chikako (Department of Mental Retardation and Birth Defect Research, NCNP, Tokyo, Japan) ,  Inoue Ken (Department of Mental Retardation and Birth Defect Research, NCNP, Tokyo, Japan) ,  Goto Yu-ichi (Department of Mental Retardation and Birth Defect Research, NCNP, Tokyo, Japan) ,  Nabeshima Yoichi (Foundation for Biomedical Research and Innovation, Kobe, Japan) ,  Ihara Nobuo (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Yamakawa Kazuhiro (Graduate School of Medical Science, Nagoya City University, Nagoya, Japan) ,  Taya Shinichiro (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan) ,  Hoshino Mikio (Department of Biochemistry and Cellular Biology, National Institute of Neuroscience, National Center of Neurology and Psychiatry (NCNP), Kodaira, Japan)
Material： Acta Neuropathologica Communications (Web)
Volume： 8  Issue： 1  Page： 1-17  Publication year： 2020 
JST Material Number： U7296A  ISSN： 2051-5960  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： The Ihara epileptic rat (IER) ...

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Thesaurus term： amino acid ,  epilepsy ,  mutation ,  human(primates) ,  rat ,  image processing ,  cortex(animal tissue) ,  *cell adhesion ,  dentate gyrus ,  *seizure(disease) ,  kindling ,  pathological state ,  aliphatic amine ,  aliphatic carboxylic acid ,  aminocarboxylic acid ,  primary amine
Semi thesaurus term： 嗅内皮質 ,  ノックインマウス , 【Automatic Indexing@JST】

Author keywords (5)： DSCAML1 ,  Seizure susceptibility ,  Ihara epileptic rat ,  Gabaergic neurons ,  Patient-type model mouse

JST classification (2)： Basic neurology  (GN01020W) ,  Central nervous system  (EJ12030F)

Substance index (1)： GABA

Reference (41)：

• Nature; De novo mutations in epileptic encephalopathies; ; 501; 2013; 217-221; 10.1038/nature12439; citation_id=CR1
• Am J Hum Genet; De novo mutations in synaptic transmission genes including DNM1 cause epileptic encephalopathies; ; 100; 2017; 179; 10.1016/j.ajhg.2014.08.013; citation_id=CR2
• Am J Pathol; Development of a novel rat mutant with spontaneous limbic-like seizures; S Amano, N Ihara, S Uemura, M Yokoyama, M Ikeda, T Serikawa; 149; 1996; 329-333; citation_id=CR3
• Lab Anim Sci; High performance seizure-monitoring system using a vibration sensor and videotape recording: behavioral analysis of genetically epileptic rats; S Amano, M Yokoyama, R Torii, J Fukuoka, K Tanaka, N Ihara; 47; 1997; 317-320; citation_id=CR4
• Brain Res; Neuronal microdysgenesis and acquired lesions of the hippocampal formation connected with seizure activities in Ihara epileptic rat; A Tsuji, S Amano, M Yokoyama, J Fukuoka, Y Hayase, M Matsuda; 901; 2001; 1-11; 10.1016/s0006-8993(01)01994-1; citation_id=CR5

Terms in the title (5)： ダウン症候群 ,  細胞接着分子 ,  GABA ,  発作 ,  感受性