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J-GLOBAL ID：202102291625406881   Reference number：21A0099236

Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy in streptozotocin-induced diabetic nude mice: the role of angiogenic and neurotrophic factors

ヒト歯髄幹細胞の移植はストレプトゾトシン誘導糖尿病ヌードマウスにおける糖尿病性多発神経障害を改善する:血管新生と神経栄養因子の役割【JST・京大機械翻訳】

Author (21)： Hata Masaki (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Omi Maiko (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Kobayashi Yasuko (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Nakamura Nobuhisa (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Miyabe Megumi (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Ito Mizuho (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Makino Eriko (Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Kanada Saki (Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Saiki Tomokazu (Department of Pharmacy, Dental Hospital, Aichi Gakuin University, Nagoya, Japan) ,  Ohno Tasuku (Department of Periodontology, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Imanishi Yuka (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Himeno Tatsuhito (Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Kamiya Hideki (Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Nakamura Jiro (Division of Diabetes, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute, Japan) ,  Ozawa Shogo (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Miyazawa Ken (Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Kurita Kenichi (Department of Oral and Maxillofacial Surgery, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Goto Shigemi (Department of Orthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Takebe Jun (Department of Removable Prosthodontics, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Matsubara Tatsuaki (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan) ,  Naruse Keiko (Department of Internal Medicine, School of Dentistry, Aichi Gakuin University, Nagoya, Japan)
Material： Stem Cell Research & Therapy (Web)
Volume： 11  Issue： 1  Page： 1-11  Publication year： 2020 
JST Material Number： U7397A  ISSN： 1757-6512  Document type： Article
Article type： 原著論文  Country of issue： United Kingdom (GBR)  Language： ENGLISH (EN)

Abstract/Point： Dental pulp stem cells (DPSCs)...

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Thesaurus term： gene ,  blood flow ,  sciatic nerve ,  protein ,  *diabetes mellitus ,  human(primates) ,  rat ,  *nude mouse ,  gastrocnemius muscle ,  *neurotrophic factor ,  *angiogenesis ,  VEGF
Semi thesaurus term： 多発性神経障害 ,  多分化能 ,  *歯髄幹細胞 , 【Automatic Indexing@JST】

Author keywords (7)： Human dental pulp stem cells (hDPSCs) ,  Diabetic polyneuropathy ,  Cell therapy ,  Regenerative medicine ,  Diabetes ,  NGF ,  VEGF

JST classification (2)： Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic neurology  (GN01020W)

Reference (34)：

• J Dental Res; Stem cell properties of human dental pulp stem cells; S Gronthos, J Brahim, W Li, L Fisher, N Cherman, A Boyde; 81; 2002; 531-535; 10.1177/154405910208100806; citation_id=CR1
• J Cell Physiol; Long-term cryopreservation of dental pulp stem cells (SBP-DPSCs) and their differentiated osteoblasts: a cell source for tissue repair; G Papaccio, A Graziano, R d’Aquino, MF Graziano, G Pirozzi, D Menditti; 208; 2006; 319-325; 10.1002/jcp.20667; citation_id=CR2
• Stem Cell Res Ther; Transplantation of cultured dental pulp stem cells into the skeletal muscles ameliorated diabetic polyneuropathy: therapeutic plausibility of freshly isolated and cryopreserved dental pulp stem cells; M Hata, M Omi, Y Kobayashi, N Nakamura, T Tosaki, M Miyabe; 6; 2015; 162; 10.1186/s13287-015-0156-4; citation_id=CR3
• Transplantation; Multipotent mesenchymal stem cells with immunosuppressive activity can be easily isolated from dental pulp; L Pierdomenico, L Bonsi, M Calvitti, D Rondelli, M Arpinati, G Chirumbolo; 80; 2005; 836-842; 10.1097/01.tp.0000173794.72151.88; citation_id=CR4
• Diabetologia; Diabetic neuropathies; AI Vinik, TS Park, KB Stansberry, GL Pittenger; 43; 2000; 957-973; 10.1007/s001250051477; citation_id=CR5

Terms in the title (11)： ヒト ,  歯髄幹細胞 ,  移植 ,  ストレプトゾトシン ,  誘導 ,  糖尿病 ,  ヌードマウス ,  糖尿病性多発神経障害 ,  血管新生 ,  神経栄養因子 ,  役割