Rchr
J-GLOBAL ID：202201001173401024
Update date: Jun. 07, 2024
HOSOGI Shigekuni
ホソギ シゲクニ | HOSOGI Shigekuni
Affiliation and department：
Job title：
Associate Professor
Research field (1)：
Respiratory medicine
Research keywords (1)：
molecular cell physiology, pulmonary-airway physiology,clinical oncology
Research theme for competitive and other funds (10)：
- 2021 - 2024 Verification of clinical usefulness obtained in basic and clinical research with real-world data
- 2020 - 2023 Elucidation of the pathogenesis of pulmonary fibrosis mediated by dopamine receptors and development of novel therapeutic agents
- 2019 - 2022 Nanometer scale resolution imaging of pH and reactive oxygen species on the outer membrane surface for fast and effective cell discrimination in cancer tissues.
- 2017 - 2020 Development of airway mucociliary transport system activation therapy targeting ion transporters in COPD
- 2014 - 2017 the pH reguration system is new target of cancer stem cells
- 2013 - 2016 Molecular mechanisms of cancer metastasis induced by disrupting the WNK kinase mediated cytosolic Cl- homeostasis
- 2013 - 2015 Continuous pH measurement of interstitial fluid and clarification of pathogenic mechanism of insulin resistance by ISFET pH sensor
- 2012 - 2015 Inhibitory mechanism of quercetin on ENaC in salt-sensitive hypertension
- 2012 - 2014 The regulation of cytosolic chloride ion concentration which regulates autophagy system via regulation of lysosome acidity is a new target for cancer therapy
- 2011 - 2012 Challenging study of immunotherapy for osteosarcoma usingmicroparticles induced by photodynamic therapy
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Papers (20)：
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Daiki Shimizu, Miku Ishibashi, Tadaaki Yamada, Yuki Toda, Shigekuni Hosogi, Eishi Ashihara. POLD1 Is Required for Cell Cycle Progression by Overcoming DNA Damage in Malignant Pleural Mesothelioma. Cancer genomics & proteomics. 2024. 21. 2. 158-165
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Toma Matsui, Yuki Toda, Haruka Sato, Rina Itagaki, Kazuya Konishi, Anna Moshnikova, Oleg A Andreev, Shigekuni Hosogi, Yana K Reshetnyak, Eishi Ashihara. Targeting acidic pre-metastatic niche in lungs by pH low insertion peptide and its utility for anti-metastatic therapy. Frontiers in oncology. 2023. 13. 1258442-1258442
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Emi Soma, Asako Yamayoshi, Yuki Toda, Yuji Mishima, Shigekuni Hosogi, Eishi Ashihara. Successful Incorporation of Exosome-Capturing Antibody-siRNA Complexes into Multiple Myeloma Cells and Suppression of Targeted mRNA Transcripts. Cancers. 2022. 14. 3. 566-566
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Shigekuni Hosogi, Yoshinori Marunaka, Eishi Ashihara, Tadaaki Yamada, Ayumi Sumino, Hideo Tanaka, Leonardo Puppulin. Plasma membrane anchored nanosensor for quantifying endogenous production of H2O2 in living cells. Biosensors and Bioelectronics. 2021. 179. 113077-113077
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Yuki Toda, Ryosuke Yoshimura, Masao Itahara, Yuri Imai, Kanae Yamada, Tomoko Uno, Susumu Nakata, Shigekuni Hosogi, Kazuyuki Takata, Eishi Ashihara. DJ-1 Contributes to Self-renewal of Stem Cells in the U87-MG Glioblastoma Cell Line. Anticancer research. 2019. 39. 11. 5983-5990
ｍore...
MISC (3)：
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Wataru Aoi, Shigekuni Hosogi, Naomi Niisato, Noriko Yokoyama, Hiroki Hayata, Hiroaki Miyazaki, Katsuyuki Kusuzaki, Takuya Fukuda, Michiaki Fukui, Naoto Nakamura, et al. Improvement of insulin resistance, blood pressure and interstitial pH in early developmental stage of insulin resistance in OLETF rats by intake of propolis extracts. Biochemical and Biophysical Research Communications. 2013. 432. 4. 650-653
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Maki Kitagawa, Naomi Niisato, Shigekuni Hosogi, Atsushi Shiozaki, Eigo Otsuji, Yoshinori Marunaka. A role of K+-Cl- cotransporter in the cell cycle regulation of breast cancer MDA-MB-231 cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S137-S137
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Yoshinori Marunaka, Shigekuni Hosogi. Roles of hydrogen and chloride ions in proliferation of MKN28 Human Gastric Cancer Cells. JOURNAL OF PHYSIOLOGICAL SCIENCES. 2013. 63. S84-S84
Lectures and oral presentations (2)：
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An artichoke-derived compound increases [Ca2+]i via inhibiting Sarco/Endoplasmic Reticulum Ca2+-ATPase (SERCA) activated airway ciliary beating in human
(European respiratory society 2022)
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Ginseng derived Kpu-230 activate human airway mucociliary clearance via activation of estrogen receptor.
(2022)
Education (1)：
- 1992 - 1998 Kyoto Prefectural University of Medicine
Work history (5)：
- 2018/10 - 現在 Kyoto Pharmaceutical University Clinical and Translational Physiology Associate Professor
- 2016/04 - 2018/10 Kyoto Prefectural University of Medicine Graduate School of Medical Science Senior lecturer
- 2009/04 - 2015/03 Kyoto Prefectural University of Medicine Molecular Cell Physiology Assistant Professor
- 2013/09 - 2014/12 Bologna University Biomedical and Neuromotor Sciences Visitting Professor
- 2007/04 - 2009/03 Kyoto Prefectural University of Medicine Respiratory Medicine Assistnant Professor
Awards (3)：
- 2014/03 - the 91th annual meeting of the physiological society of Japan Poster award
- 2012/10 - The 3rd Symposium of the International Society of Proton Dynamics in Cancer Young investigator award
- 2012/03 - Poster award The 89th annual meeting of the physiological society of Japan
Association Membership(s) (6)：
日本がん予防学会
, 日本がん分子標的治療学会
, Physiological society of Japan
, Japan Respiratory Society
, 日本薬学会
, 日本癌学会
