Suzuki Yuta

スズキユウタ | Suzuki Yuta

Affiliation and department：
Homepage URL (1)： https://scholar.google.co.jp/citations?hl=ja&user=21VoIxUAAAAJ&view_op=list_works

Research keywords (4)：薬剤学 , 製剤学 , 核酸医薬 , ペプチド医薬

Research theme for competitive and other funds (5)：

2022 - 2025 小児ネフローゼ症候群のワクチン療法の開発
2018 - 2025 新規の核酸合成とデリバリー技術を用いた核酸創薬研究
2023 - 2024 生体内蛋白質医薬品生産技術プラットフォームの確立と緊急時国内製造のための基盤整備
2022 - 2023 生体内蛋白質医薬品生産技術に基づくNext COVID-19治療薬の開発
2021 - 2022 抗体医薬の迅速供給を可能とする体内抗体産生技術基盤の構築

Papers (38)：

Iori Mizogaki, Takuya Suzuki, Ryo Ohori, Syusuke Sano, Shoki Hara, Takayuki Miyazaki, Kenji Kubara, Yoko Ida, Keita Kondo, Yuta Suzuki, et al. Evaluating the impact of lyophilization process parameters on mRNA encapsulated lipid nanoparticles using machine learning. Journal of Drug Delivery Science and Technology. 2025
Shoki Hara, Takuya Suzuki, Iori Mizogaki, Takayuki Miyazaki, Keita Kondo, Shuntaro Arase, Yuta Suzuki, Shinya Sato, Koji Ukai. Anion-exchange high-performance liquid chromatography: A new approach to monitoring the formation of mRNA-loaded lipid nanoparticles during manufacturing. Journal of Pharmaceutical Sciences. 2025. 104031-104031
Hiroki Muto, Kenji Kubara, Seiji Hitaoka, Yoshihide Osada, Yuta Suzuki. Ionizable lipid chemistry in lipid nanoparticles determines delivery efficiency to hepatic stellate cells. Journal of controlled release : official journal of the Controlled Release Society. 2025. 385. 114055-114055
Kohta Mohri, Takayuki Miyazaki, Shota Warashina, Maiko Takahashi, Qin Ren, Riho Iida, Yasuhiro Wada, Kazuya Maeda, Yasuyoshi Watanabe, Yuta Suzuki, et al. Positron Emission Tomography-Based Pharmacokinetics of mRNA-Lipid Nanoparticles: A Study Quantifying the ApoE and Macrophage Contribution. ACS Applied Materials & Interfaces. 2025
Kazuto Yamazaki, Kenji Kubara, Go Sugahara, Hiroki Muto, Masae Yamamoto, Yuji Mano, Kaoru Mitsuhashi, Chihiro Yamasaki, Yuji Ishida, Chise Tateno, et al. Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment. Molecular Therapy Methods & Clinical Development. 2025. 33. 2. 101466-101466

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MISC (2)：

Ishigooka H., Motoi S., Yamakawa T., Matsui C., Suzuki Y., Ishii R., Saiga K., Tokita D., Imai T., Tanabe K. Successful Prophylaxis of Antibody-Mediated Rejection by Downregulation of C5 Expression via RNA Interference in a Rat Kidney Transplant Model. Am J Transplant. 2021. 21. suppl 3
Yasutomo Segawa, Yuta Suzuki, Makoto Yamashita, Kyoko Nozaki. INOR 78-Boryllithium chemistry: Synthesis, structures in solid and solution state, and reactivities toward organic molecules. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY. 2008. 235

Patents (14)：

POLYNUCLEOTIDE AND PRODUCING METHOD THEREOF
PHARMACEUTICAL COMPOSITION
LIPID COMPLEX
PHARMACEUTICAL COMPOSITION CONTAINING DOUBLE-STRANDED RIBONUCLEIC ACID INHIBITING EXPRESSION OF COMPLEMENT C5
NUCLEIC ACID COMPLEX AND PHARMACEUTICAL COMPOSITION CONTAINING SAME

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Lectures and oral presentations (34)：

Minimal chemical modification to the 3′-poly(A) terminus elicit durable protein expression of linear mRNA in mice and non-human primates
(13th International mRNA Health Conference 2025)
Attenuation of mouse drug-metabolism via lipid nanoparticles formulated species-specific siRNA targeting P450 oxidoreductase (Por) gene in humanized liver of chimeric mouse
(2025)
mRNAを用いた生体内蛋白質医薬品生産技術プラットフォームの確立
(日本化学会秋季事業第15回 CSJ化学フェスタ 2025)
Species-specific gene expression manipulation in humanized livers of chimeric mice via siRNA-encapsulated lipid nanoparticle treatment
(2025)
In vivo production of engineered ACE2 decoy protects lungs from SARS-CoV-2 infection
(第15回エリクサジェン・サイエンティフィックウェビナー 2025)

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Education (3)：

2017 - The University of Tokyo Graduate School of Pharmaceutical Sciences
2007 - 2009 東京大学大学院工学系研究科化学生命工学専攻
2003 - 2007 The University of Tokyo The Faculty of Engineering Department of Chemistry and Biotechnology

Work history (4)：

2021/05 - 2023/03 理化学研究所客員研究員
2022/10 - エーザイグループ長
2020/04 - エーザイ主幹研究員
2009/04 - エーザイ

Committee career (4)：

2025/04 - 現在日本核酸医薬学会, DDSセッション主任幹事
2022/08 - 2025/03 日本核酸医薬学会 DDSセッション副主任幹事
2021/04 - 2023/08 日本核酸医薬学会広報セッション幹事
2021/08 - 2022/07 日本核酸医薬学会 DDSセッション幹事

Awards (2)：

2023/09 - ACS Editors’ choice Differences and Similarities of the Intravenously Administered Lipid Nanoparticles in Three Clinical Trials: Potential Linkage between Lipid Nanoparticles and Extracellular Vesicles
2009/03 - 東京大学大学院工学系研究科長賞(修士)

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