Yoshimoto Ryo

ヨシモトリョウ | Yoshimoto Ryo

Affiliation and department：
Job title： Professor

Research field (2)： Veterinary medicine , Pharmacology

Research keywords (4)：中鎖脂肪酸 , 肥満 , サルコペニア , 創薬

Research theme for competitive and other funds (1)：

2010 - 2011 Role of LOX-1 in the development of non-alcoholic steat ohepatitis(NASH)

Papers (35)：

Ayumi Kato, Mana Ito, Takao Sanaki, Tomohiko Okuda, Noriko Tsuchiya, Ryo Yoshimoto, Hideo Yukioka. Acsl1 is essential for skin barrier function through the activation of linoleic acid and biosynthesis of ω-O-acylceramide in mice. Biochimica et biophysica acta. Molecular and cell biology of lipids. 2022. 1867. 2. 159085-159085
Kyohei Hayashi, Noriyasu Kondo, Naoki Omori, Ryo Yoshimoto, Megumi Hato, Shuhei Shigaki, Ayumi Nagasawa, Mana Ito, Takayuki Okuno. Discovery of a benzimidazole series as the first highly potent and selective ACSL1 inhibitors. Bioorganic & medicinal chemistry letters. 2021. 33. 127722-127722
Kosuke Takemoto, Yumiko Fukasaka, Ryo Yoshimoto, Hirohide Nambu, Hideo Yukioka. Diacylglycerol acyltransferase 1/2 inhibition induces dysregulation of fatty acid metabolism and leads to intestinal barrier failure and diarrhea in mice. Physiological reports. 2020. 8. 15. e14542
Masatoshi Hori, Futoshi Yazama, Yasuhiro Matsuura, Ryo Yoshimoto, Takeharu Kaneda, Takeshi Yasumoto, Hiroshi Ozaki, Hideaki Karaki. Inhibition of actin polymerization by marine toxin pectenotoxin-2. The Journal of veterinary medical science. 2018. 80. 2. 225-234
Jinqi Liu, Judith N Gorski, Stephen J Gold, Dunlu Chen, Shirley Chen, Gail Forrest, Yoshiki Itoh, Donald J Marsh, David G McLaren, Zhu Shen, et al. Pharmacological inhibition of diacylglycerol acyltransferase 1 reduces body weight and modulates gut peptide release--potential insight into mechanism of action. Obesity (Silver Spring, Md.). 2013. 21. 7. 1406-15

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MISC (6)：

善本亮, 西塚太一, 中野厚史, 藤田佳子, 垣野明美, 高谷智英, 沢村達也. プロシアニジンは酸化LDLとLOX-1の結合を阻害し、血管壁脂質沈着を抑制する. 生存科学B. 2012. 22. 27-43
垣野明美, 西塚太一, 藤田佳子, 佐藤優子, 中野厚史, 善本亮, 沢村達也. 天然物から見出したLOX-1アンタゴニスト・プロシアニジンはSHRSP血管壁への脂質沈着を抑制する. 日本内分泌学会雑誌. 2011. 87. 2. 789-789
Taichi Nishizuka, Yoshiko Fujita, Yuko Sato, Atushi Nakano, Akemi Kakino, Shunji Ohshima, Tomomasa Kanda, Ryo Yoshimoto, Tatsuya Sawamura. Procyanidins are potent inhibitors of LOX-1: a new player in the French Paradox (vol 87, pg 104, 2011). PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES. 2011. 87. 7. 431-431
Yoshiko Fujita, Akemi Kakino, Yuko Sato, Ryo Yoshimoto, Tatsuya Sawamura. C-reactive protein (CRP) uptake by macrophage via class A scavenger receptor (SR-A). JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 61P-61P
堀正敏, 松浦康浩, 善本亮, 尾崎博, 安元健, 唐木英明. 海洋由来天然生理活性物質,ペクテノトキシン-2のアクチン重合阻害作用. 日本薬理学雑誌. 1999. 114. 補冊1. 225P-229P

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Books (2)：

獣医薬理学 <第2版>
近代出版 2021
ヒスタミンH3受容体アゴニストを用いたメタボリックシンドロームの治療・予防の可能性
Bionics(オーム社) 2007

Lectures and oral presentations (35)：

運動による過負荷時・廃用からの再負荷時における筋形成過程の寄与
(日本筋学会学術集会プログラム・抄録集 2018)
3次元培養システムを活用したin vitro筋機能評価への取り組み
(日本筋学会学術集会プログラム・抄録集 2018)
Effects of 11b-HSD1 inhibitor on the muscle atrophy induced by the glucocorticoid excess.
(8th International Conference on Cachexia, Sarcopenia and Muscle Wasting, Paris, France 1900)
雄ラットにおけるStreptozotocin 誘発性膵島腫瘍の病理学的及び網羅的遺伝子解析
(第31回日本毒性病理学会総会)
Procyanidin is a naturally-occurnig LOX-1 antagonist and inhibits lipid accumulation in vascular wall.
(第84回日本薬理学会年会、横浜)

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Education (1)：

1997 - 2001 The University of Tokyo

Work history (4)：

2022/04 - 現在 Azabu University
2011/07 - 2022/03 塩野義製薬株式会社医薬研究本部
2009/06 - 2011/06 National Cerebral and Cardiovascular Center, Research Institute
2001/04 - 2009/05 万有製薬株式会社つくば研究所

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