Rchr
J-GLOBAL ID:202201006094192292
Update date: Aug. 27, 2025
otani shohei
オオタニ ショウヘイ | otani shohei
Affiliation and department:
Nagasaki University Graduate School of Biomedical Sciences
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Detailed information
Job title:
Assistant professor
Research field (2):
Oral medicine (pathology)
, Tumor biology
Research theme for competitive and other funds (6):
2025 - 2027 筋由来exosomeを介した新規がん悪性化メカニズムの解明
2024 - 2027 新規がん化機軸をターゲットにした抗p53欠損型腫瘍戦略
2024 - 筋由来 exosome を介した新たな口腔がん悪性化メカニズムの解明
2024 - 新規がん化機軸をターゲットにした抗p53欠損型腫瘍戦略
2024 - 新規がん化機軸を標的にした抗p53欠損型腫瘍戦略
2022 - 2024 骨肉腫発症における新規γグルタミル回路調節因子の役割
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Papers (10):
Tomoya Ueno, Shohei Otani, Yuki Date, Yu Katsuma, Yuma Nagayoshi, Tomoko Ito, Hiromi Ii, Susumu Kageyama, Susumu Nakata, Kosei Ito. Myc upregulates Ggct, γ-glutamylcyclotransferase to promote development of p53-deficient osteosarcoma. Cancer science. 2024
Keisuke Omori, Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Masahiro Umeda, Kosei Ito. C/ebpα represses the oncogenic Runx3-Myc axis in p53-deficient osteosarcoma development. Oncogene. 2023
Shohei Otani, Mizuho Ohnuma, Kosei Ito, Yuki Matsushita. Cellular dynamics of distinct skeletal cells and the development of osteosarcoma. Frontiers in Endocrinology. 2023. 14
Kosei Ito, Shohei Otani, Yuki Date. p53 Deficiency-Dependent Oncogenicity of Runx3. Cells. 2023. 12. 8
Shohei Otani, Yuki Date, Tomoya Ueno, Tomoko Ito, Shuhei Kajikawa, Keisuke Omori, Ichiro Taniuchi, Masahiro Umeda, Toshihisa Komori, Junya Toguchida, et al. Runx3 is required for oncogenic Myc upregulation in p53-deficient osteosarcoma. Oncogene. 2022. 41. 5. 683-691
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MISC (7):
伊藤公成, 上野智也, 大谷昇平, 伊達悠貴. TGFβ signaling facilitates Myc upregulation by Runx in p53-deficient osteosarcoma development. 日本癌学会学術総会抄録集(Web). 2022. 81st
大谷昇平, 伊達悠貴, 伊藤公成. 転写因子RUNXの「がん遺伝子」としての役割. 日本進化学会大会プログラム・講演要旨集(Web). 2022. 24th
Yuki Date, Shohei Otani, Tomoya Ueno, Kosei Ito. Abstract 301: RUNX3 upregulatesc-MYCviamR1- an essential genomic element forp53-deficient osteosarcomagenesis. Molecular and Cellular Biology / Genetics. 2020
大谷昇平, 伊達悠貴, 伊藤公成. p53 represses c-Myc by inhibition of Runx3 to suppress osteosarcoma development. 日本癌学会学術総会抄録集(Web). 2019. 78th
六反田 賢, 大森 景介, 津田 翔真, 坂元 裕, 大谷 昇平, 梅田 正博. 歯根嚢胞に対する手術時に止血困難を生じた血友病Bの1例. 日本口腔外科学会雑誌. 2018. 64. 6. 374-380
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Lectures and oral presentations (8):
新規がん化機軸を標的にした抗p53欠損型腫瘍戦略
(第66回歯科基礎医学会学術大会 2024)
p53機能欠損下における転写因子Runx3の「がん遺伝子」としての役割
(第5回口腔医科学フロンティア研究会 2023)
転写因子RUNXの「がん遺伝子」としての役割
(第24回日本進化学会 2022)
RUNX3 upregulates c-MYC via mR1-an essential genomic element for p53- deficient osteosarcoma-genesis
(AACR Annual Meeting 2020)
p53 represses c-Myc by inhibition of Runx3 to suppress osteosarcoma development
more...
Education (2):
2014 - 2022 Nagasaki University Graduate School of Biomedical Sciences
2007 - 2013 Nagasaki University School of Dentistry
Professional career (1):
博士(歯学) (Nagasaki University)
Work history (4):
2022/04 - 現在 Nagasaki University Graduate School of Biomedical Sciences
2021/05 - 2022/03 Nagasaki University Graduate School of Biomedical Sciences
2014/04 - 2015/03 長崎大学病院 口腔腫瘍治療学 歯科修練医
2013/04 - 2014/03 長崎大学病院 歯科研修医
Association Membership(s) (3):
歯科基礎医学会
, 日本癌学会
, 日本口腔外科学会
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