Rchr
J-GLOBAL ID:202201007472030774
Update date: Jan. 31, 2024
masaki toshihiro
まさき としひろ | masaki toshihiro
Affiliation and department:
Job title:
Professor
Research field (5):
Cell biology
, Rehabilitation science
, Bacteriology
, Neurology
, Neurology
Research keywords (7):
Schwann cell
, stem cell
, regenerative medicine
, peripheral neuropathy
, Leprosy
, アルコール依存症
, 遺伝子多型
Research theme for competitive and other funds (13):
- 2023 - 2027 Novel regeneraive rehabilitation of stroke supported by pharmacological neuromodulation
- 2021 - 2024 Regenerative rehabilitation of stroke supported by epigenetics
- 2020 - 2024 薬理的神経制御を用いた新たな脳卒中運動療法の開発に対する生体脳イメージングの応用
- 2019 - 2023 先進的ゲノム編集技術を用いた難治性神経筋疾患に対する治療戦略
- 2018 - 2021 Development of a novel method of regenerative therapy on tissues associated with locomotion using M.leprae-induced stem cells and Schwann cells
- 2017 - 2021 Development of exercise therapy combined with pharmacological treatment of synaptic transmission for stroke rehabilitation
- 2016 - 2019 Significance of dystroglycan processing and its participation in the pathogenesis of neuromuscular disorders
- 2015 - 2018 Therapeutic strategy for muscular dystrophy via regulation of STIM1 mediated Ca2+ homeostasis
- 2014 - 2017 Molecular mechanism of stem cell-inducing reprogramming by epithelial mesenchymal transition
- 2014 - 2017 Development of glycosyltransferase replacement therapy for muscular dystrophy caused by alpha-dystroglycanopathy
- 2013 - 2016 Characterization of the function of dystroglycan N-terminal domain and its related disorders in nervous system
- 2013 - 2016 Long-term therapeutic potential of resveratrol on the progression of muscle atrophy in a mouse model of congenital muscular dystrophy
- 2011 - 2013 characterization of the laminin-dystroglycan interaction in neuropathy and its therapeutic application
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Papers (31):
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Miki Ikeda, Mariko Taniguchi-Ikeda, Takema Kato, Yasuko Shinkai, Sonoko Tanaka, Hiroki Hagiwara, Naomichi Sasaki, Toshihiro Masaki, Kiichiro Matsumura, Masahiro Sonoo, et al. Unexpected Mutations by CRISPR-Cas9 CTG Repeat Excision in Myotonic Dystrophy and Use of CRISPR Interference as an Alternative Approach. Molecular therapy. Methods & clinical development. 2020. 18. 131-144
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Fumiaki Saito, Motoi Kanagawa, Miki Ikeda, Hiroki Hagiwara, Toshihiro Masaki, Hidehiko Ohkuma, Yuki Katanosaka, Teruo Shimizu, Masahiro Sonoo, Tatsushi Toda, et al. Overexpression of LARGE suppresses muscle regeneration via down-regulation of insulin-like growth factor 1 and aggravates muscular dystrophy in mice. Human molecular genetics. 2014. 23. 17. 4543-58
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Toshihiro Masaki, Aidan McGlinchey, Justyna Cholewa-Waclaw, Jinrong Qu, Simon R Tomlinson, Anura Rambukkana. Innate immune response precedes Mycobacterium leprae-induced reprogramming of adult Schwann cells. Cellular reprogramming. 2014. 16. 1. 9-17
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Toshihiro Masaki, Jinrong Qu, Justyna Cholewa-Waclaw, Karen Burr, Ryan Raaum, Anura Rambukkana. Reprogramming adult Schwann cells to stem cell-like cells by leprosy bacilli promotes dissemination of infection. Cell. 2013. 152. 1-2. 51-67
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Toshihiro Masaki, Aidan McGlinchey, Simon R Tomlinson, Jinrong Qu, Anura Rambukkana. Reprogramming diminishes retention of Mycobacterium leprae in Schwann cells and elevates bacterial transfer property to fibroblasts. F1000Research. 2013. 2. 198-198
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MISC (1):
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S. Papapetropoulos, A. A. Argyriou, Keiko Kamakura, Hitoshi Mochizuki, Ken-Ichi Kaida, Akira Hirata, Toshihiro Masaki, Ryohji Nakamura. Administration of selegiline is not associated with visual hallucinations in advanced Parkinson's disease patients (multiple letters). Parkinsonism and Related Disorders. 2005. 11. 4. 265-267
Books (1):
-
酒乱になる人、ならない人 (新潮新書)
新潮社 2003 ISBN:4106100487
Education (3):
- 1981 - 1985 The University of Tokyo Faculty of Medicine
- 1979 - 1981 The University of Tokyo College of Arts and Sciences
- 1976 - 1979 松江北高校
Work history (17):
- 2018/04 - 現在 Teikyo University of Science & Technology
- 2014/08 - 現在 University of Edinburgh honorary fellow/visiting scientist
- 2010/04 - 2018/03 Teikyo University of Science & Technology Faculty of Medical Sciences
- 2009/07 - 2010/03 University of Edinburgh Centre for neuroregeneration Senior postdoctoral fellow
- 2007/04 - 2009/06 The Rockefeller University Laboratory of Bacterial Pathogenesis and Immunology Research Associate
- 2000/07 - 2006/03 国立病院機構久里浜病院 神経内科 医長
- 2003/11 - 2005/10 The Rockefeller University Laboratory of Bacterial Pathogenesis and Immunology Research Associate
- 1995/01 - 2000/06 National Defense Medical College
- 1994/07 - 1994/12 横浜労災病院 病理部 医師
- 1993/04 - 1994/06 虎の門病院 神経内科 医師
- 1992/10 - 1993/03 The University of Tokyo Faculty of Medicine University Hospital Department of Neurology
- 1990/04 - 1992/09 National Center of Neurology and Psychiatry
- 1989/06 - 1990/03 東京逓信病院 内科 医師
- 1988/06 - 1989/05 日本赤十字社医療センター 神経内科 医師
- 1987/06 - 1988/05 国立病院機構下志津病院 神経内科 医師
- 1986/06 - 1987/05 東京都立老人医療センター 医師
- 1985/06 - 1986/05 東京大学付属病院 医師
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Awards (1):
- 2013 - Cell Press Cell's "Best of 2013"
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