Rchr
J-GLOBAL ID：202201008543365884
Update date: Oct. 09, 2024
YOSHINO Ryunosuke
ヨシノ リュウノスケ | YOSHINO Ryunosuke
Affiliation and department：
Job title：
Assistant Professor
Research keywords (1)：
Computational Chemistry, Molecular Simulation
Research theme for competitive and other funds (3)：
- 2024 - 2026 Detection of oncodomains using mutation accumulation as an Indicator
- 2018 - 2020 Pharmacophore modeling using interaction analysis information by Fragment Molecular Orbital method
- 2016 - 2018 インシリコ技術を用いたシャーガス病治療薬の開発
Papers (26)：
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Genki Kudo, Takumi Hirao, Ryuhei Harada, Takatsugu Hirokawa, Yasuteru Shigeta, Ryunosuke Yoshino. Prediction of the binding mechanism of a selective DNA methyltransferase 3A inhibitor by molecular simulation. Scientific reports. 2024. 14. 1. 13508-13508
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Kudo, Genki, Hirao, Takumi, Yoshino, Ryunosuke, Shigeta, Yasuteru, Hirokawa, Takatsugu. Site Identification and Next Choice Protocol for Hit-to-Lead Optimization. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2024. 64. 11. 4475-4484
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Kudo, Genki, Yanagisawa, Keisuke, Yoshino, Ryunosuke, Hirokawa, Takatsugu. AAp-MSMD: Amino Acid Preference Mapping on Protein-Protein Interaction Surfaces Using Mixed-Solvent Molecular Dynamics. JOURNAL OF CHEMICAL INFORMATION AND MODELING. 2023. 63. 24. 7768-7777
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Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Takashi Ishida, Daniel Ken Inaoka, Yasushi Amano, Yukihiro Tateishi, Kazuki Ohno, Ichiji Namatame, Tatsuya Niimi, et al. Discovery of a Hidden Trypanosoma cruzi Spermidine Synthase Binding Site and Inhibitors through In Silico, In Vitro, and X-ray Crystallography. ACS Omega. 2023
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Saito, Kenji, Sekiya, Motohiro, Kainoh, Kenta, Yoshino, Ryunosuke, Hayashi, Akio, Han, Song-Iee, Araki, Masaya, Ohno, Hiroshi, Takeuchi, Yoshinori, Tsuyuzaki, Tomomi, et al. Obesity-induced metabolic imbalance allosterically modulates CtBP2 to inhibit PPAR-alpha transcriptional activity. J Biol Chem. 2023. 299. 7. 104890-104890
ｍore...
MISC (2)：
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Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Shigeharu Harada, Teruki Honma, Daniel KenInaoka, Kiyoshi Kita, et al. Protein-ligand interaction energy analysis between anti-trypanosome drug candidate and target protein using fragment molecular orbital. IPSJ SIG Notes. 2013. 2013. 5. 1-7
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Ryunosuke Yoshino, Nobuaki Yasuo, Yohsuke Hagiwara, Kazuki Ohno, Masaya Orita, Masayuki Inoue, Shigeharu Harada, Teruki Honma, Daniel KenInaoka, Kiyoshi Kita, et al. Protein-ligand interaction energy analysis between anti-trypanosome drug candidate and target protein using fragment molecular orbital. IPSJ SIG technical reports. 2013. 2013. 5. 1-7
Lectures and oral presentations (16)：
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Hit-to-Leadを指向した官能基修飾始点と伸長サイトの予測手法開発
(第 51 回構造活性相関シンポジウム)
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拡張アンサンブル法を用いたPROTACリンカー設計のための三元複合体構造探索
(第51回構造活性相関シンポジウム)
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バーチャルスクリーニングモデル作成のためのParallel Cascade Selection Molecular Dynamicsの応用
(第51回構造活性相関シンポジウム)
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Conformation Search of Ternary Complexes for Rational PROTAC Linker Design Using Enhanced Sampling Method
(CBI学会2023年大会)
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Application of Parallel Cascade Selection Molecular Dynamics for Generating Virtual Screening Models
(CBI学会2023年大会)
ｍore...
Professional career (1)：
- Doctor of Agriculture (Graduate School of Agricultural and Life Sciences, The University of Tokyo)
Work history (1)：
- 2017/04 - 2018/03 Tokyo Institute of Technology Education Academy of Computational Life Sciences Specially Appointed Assistant Professor
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