Rchr
J-GLOBAL ID:202201009427053243   Update date: Jul. 21, 2024

Yamamoto Kazuhiko

ヤマモト カズヒコ | Yamamoto Kazuhiko
Affiliation and department:
Job title: Director
Research theme for competitive and other funds  (42):
  • 2018 - 2023 Establishment of a novel strategy for pathological analysis of multifactorial diseases using genetic risk variants
  • 2015 - 2020 Elucidation of the host's homeostatic responses by the regulation of immune system and its application to the prevention and treatment of immunological disorders
  • 2011 - 2016 Development of rheumatoid arthritis-directed human immunology
  • 2011 - 2011 関節リウマチにおける自己抗原とそれに対する免疫応答制御
  • 2007 - 2011 Mechanisms and their regulation of autoimmune disorders
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Papers (188):
  • Jun Inamo, Akari Suzuki, Mahoko Takahashi Ueda, Kensuke Yamaguchi, Hiroshi Nishida, Katsuya Suzuki, Yuko Kaneko, Tsutomu Takeuchi, Hiroaki Hatano, Kazuyoshi Ishigaki, et al. Long-read sequencing for 29 immune cell subsets reveals disease-linked isoforms. Nature communications. 2024. 15. 1. 4285-4285
  • Manaka Goto, Hideyuki Takahashi, Ryochi Yoshida, Takahiro Itamiya, Masahiro Nakano, Yasuo Nagafuchi, Hiroaki Harada, Toshiaki Shimizu, Meiko Maeda, Akatsuki Kubota, et al. Age-associated CD4 + T cells with B cell-promoting functions are regulated by ZEB2 in autoimmunity. Science Immunology. 2024
  • Shinji Izuka, Toshihiko Komai, Takahiro Itamiya, Mineto Ota, Yasuo Nagafuchi, Hirofumi Shoda, Kosuke Matsuki, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio. Machine learning-driven immunophenotypic stratification of mixed connective tissue disease corroborating the clinical heterogeneity. Rheumatology (Oxford, England). 2024
  • Kazuhiko Yamamoto, Kazuyoshi Ishigaki, Yukinori Okada. How can genetics analysis allow for early detection of rheumatoid arthritis. Seminars in Arthritis and Rheumatism. 2024. 64. 152323-152323
  • Mineto Ota, Masahiro Nakano, Yasuo Nagafuchi, Satomi Kobayashi, Hiroaki Hatano, Ryochi Yoshida, Yuko Akutsu, Takahiro Itamiya, Nobuhiro Ban, Yumi Tsuchida, et al. Multimodal repertoire analysis unveils B cell biology in immune-mediated diseases. Annals of the Rheumatic Diseases. 2023. ard-2023
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MISC (16):
  • Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu, So-Young Bang, Leilei Wen, Masaru Koido, Eunji Ha, Lu Liu, Yuma Sakamoto, Sungsin Jo, et al. Meta-analysis of 208,370 East Asians identifies 113 genomic loci and yields new non-immune cell relevant biological insights for systemic lupus erythematosus. medRxiv. 2020
  • Haruyuki Yanaoka, Yasuo Nagafuchi, Yusuke Takeshima, Mineto Ota, Harumi Shirai, Yusuke Sugimori, Mai Okubo, Satomi Kobayashi, Tomohisa Okamura, Yukiko Iwasaki, et al. CHARACTERIZATION OF IMMUNE CELL SUBSETS IN PATIENTS WITH ANCA-ASSOCIATED VASCULITIS. RHEUMATOLOGY. 2017. 56. 116-116
  • Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Shinichiro Nakachi, Rika Kato, Keiichi Sakurai, Norio Hanata, et al. Gene Modules Correlated with Disease Activity and Abatacept Treatment Identified with Weighted Gene Co-Expression Network Analysis of CD4+T Cell Subsets of RA. ARTHRITIS & RHEUMATOLOGY. 2016. 68
  • Keiichi Sakurai, Hirofumi Shoda, Kazuyoshi Ishigaki, Yumi Tsuchida, Yasuo Nagafuchi, Shuji Sumitomo, Akari Suzuki, Keishi Fujio, Kazuhiko Yamamoto. Analysis of T Cell Repertoire Diversity of CD4+Memory and NaiVe T Cells By Next Generation Sequencing and Its Association with Rheumatoid Arthritis Disease Parameters. ARTHRITIS & RHEUMATOLOGY. 2016. 68
  • Haruka Tsuchiya, Shuji Sumitomo, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Mineto Ota, Yumi Tsuchida, Hiroshi Inui, Shuji Taketomi, Yuho Kadono, et al. The Comprehensive Analysis for the Transcriptional Organization of Stimuli Responses in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients. ARTHRITIS & RHEUMATOLOGY. 2016. 68
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Books (8):
  • 免疫応答と免疫病態の統合的分子理解
    南山堂 2007
  • リウマチ・アレルギー疾患を探る
    永井書店 2005
  • アレルギー病学
    朝倉書店 2002
  • 改訂2版 やさしい遺伝子工学
    日本医事新報社 1998
  • 自己免疫のメカニズム
    羊土社 1997
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Lectures and oral presentations  (78):
  • Dynamic Landscape of immune cell-specific gene regulation
    (The 13th International Forum on Rheumatoid Arthritis (IFRA2021) (Beijing, China/On-line))
  • Mapping genes to immune cells
    (EULAR (European League Against Rheumatism) (スペイン))
  • Integration of Genetic information to immune functions
    (Advanced Target Therapies(スペイン))
  • Lymphocyte subset-specific transcriptome analysis revealed the involvement of mitochondria in B cells abnormality of systemic lupus erythematosus (SLE)
    (47th Japanese Society for Immunology(日本))
  • Genetics of Human Immune System
    (McGill RIKEN symposium(カナダ))
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Education (3):
  • 1977 - 東京大学 医学部医学科 卒業
  • 1973 - 東京大学 医学部医学科 進学
  • 1971 - 東京大学 教養学部(理科三類)入学
Work history (14):
  • 2020/04 - 現在 理化学研究所 生命医科学研究センター センター長(自己免疫疾患研究チーム・チームリーダー兼任)
  • 2017/04 - 理化学研究所 生命医科学研究センター 副センター長
  • 2017/03 - 東京大学大学院 医学系研究科内科学専攻アレルギー・リウマチ学 教授 定年により退職
  • 1997/10 - 東京大学大学院 医学系研究科内科学専攻アレルギー・リウマチ学 教授
  • 1995/04 - 九州大学 生体防御医学研究所臨床免疫学部門 教授
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Awards (9):
  • 2017 - 紫綬褒章
  • 2015 - Carol Nachman Award
  • 2014 - 高峰記念第一三共賞
  • 2014 - 日本免疫学会ヒト免疫研究賞
  • 2014 - 日本医師会医学賞
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