Fukushima Toshiaki

フクシマトシアキ | Fukushima Toshiaki

Affiliation and department：
Job title： Assistant professor
Homepage URL (1)： https://komada-lab.jimdofree.com/people/

Research field (3)： Medical biochemistry , Zoological sciences , Cell biology

Research keywords (7)：増殖因子 , インスリン , シグナル伝達 , ユビキチン , がん , 腫瘍 , 糖尿病

Research theme for competitive and other funds (13)：

2022 - 2025 胎盤特異的に発現する増殖因子シグナル調節タンパク質による胎盤の発達や機能の制御
2021 - 2023 USP8の自己阻害機構の理解に基づく阻害剤開発とクッシング病治療への応用
2019 - 2021 ケモテクノロジーを活用した脱ユビキチン化酵素USP8の作用機構の解明
2018 - 2021 Regulatory mechanism of ubiquitin modification of insulin receptor substrates and its physiological and pathological significance.
2017 - 2021 The regulatory mechanism of IRS monoubiquitination, a vital process regulating insulin/IGF signaling

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Papers (50)：

Akinori Endo, Toshiaki Fukushima, Chikage Takahashi, Hikaru Tsuchiya, Fumiaki Ohtake, Sayaka Ono, Tony Ly, Yukiko Yoshida, Keiji Tanaka, Yasushi Saeki, et al. USP8 prevents aberrant NF-κB and Nrf2 activation by counteracting ubiquitin signals from endosomes. Journal of Cell Biology. 2024. 223. 3
Beni Lestari, Satomi Naito, Akinori Endo, Hidenori Nishihara, Akira Kato, Erika Watanabe, Kimitoshi Denda, Masayuki Komada, Toshiaki Fukushima. Placental Mammals Acquired Functional Sequences in NRK for Regulating the CK2-PTEN-AKT Pathway and Placental Cell Proliferation. Molecular biology and evolution. 2022. 39. 2
Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, et al. Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain. Communications biology. 2021. 4. 1. 1272-1272
Vivien Béziat, Franck Rapaport, Jiafen Hu, Matthias Titeux, Mathilde Bonnet des Claustres, Mathieu Bourgey, Heather Griffin, Élise Bandet, Cindy S Ma, Roya Sherkat, et al. Humans with inherited T cell CD28 deficiency are susceptible to skin papillomaviruses but are otherwise healthy. Cell. 2021. 184. 14. 3812-3828
Satomi Naito, Toshiaki Fukushima, Akinori Endo, Kimitoshi Denda, Masayuki Komada. Nik-related kinase is targeted for proteasomal degradation by the chaperone-dependent ubiquitin ligase CHIP. FEBS letters. 2020. 594. 11. 1778-1786

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MISC (19)：

福嶋俊明, 川口紘平. コラーゲンの細胞内輸送の分子機構 -脱ユビキチン化酵素USP8による輸送制御-. FRAGRANCE JOURNAL. 2020. 8
猪子和也, 澤田崇広, 遠藤彬則, 佐伯泰, 田中啓二, IBRAHIM Ardisasmita, 福嶋俊明, 福嶋俊明, 駒田雅之, 駒田雅之. Cushing病で見られる変異型脱ユビキチン化酵素USP8が核内で果たす役割の解明. 日本生化学会大会(Web). 2017. 90th. ROMBUNNO.3LBA-030 (WEB ONLY)-030]
High-molecular-mass complexes containing insulin receptor substrates play important roles in regulation of insulin-like activities. 2016. 74. 1. 21-25
高橋伸一郎, 福嶋俊明, 山中大介, 伯野史彦. 甲状腺細胞の増殖誘導機構. 日本甲状腺学会雑誌. 2016. 7. 1
Akifumi Kushiyama, Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Midori Fujishiro, Toshiaki Fukushima, Shin-Iciro Takahashi, Tomoichiro Asano. Involvement of Resistin-like Molecule beta in the Development of Nonalcoholic Steatohepatitis. DIABETES. 2014. 63. A466-A466

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Education (2)：

2000 - 2005 The University of Tokyo Graduate School of Agricultural and Life Sciences Animal Resource Sciences
1998 - 2000 The University of Tokyo

Professional career (1)：

Work history (3)：

2015/04 - 現在 Tokyo Institute of Technology
2010/04 - 2015/03 Hiroshima University
2005/04 - 2010/03 The University of Tokyo Graduate School of Agricultural and Life Sciences

Awards (4)：

2018/11 - 株式会社カイオム・バイオサイエンスカイオム賞
2018/04 - 長瀬財団長瀬研究振興賞
2011/03 - Gordon Research Conference “Insulin like growth factors in physiology and disease” 最優秀発表賞
2006/11 - 国際成長ホルモン・成長因子学術会議ホットトピックス賞

Association Membership(s) (2)：

日本生化学会 , 日本分子生物学会

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