Shinoda Koji

シノダコウジ | Shinoda Koji

Affiliation and department：
Job title： Research Assistant Professor

Research field (2)： Immunology , Neurology

Research keywords (3)： Neuroimmunology , Multiple Sclerosis , Neuromyelitis optica spectrum disorders

Research theme for competitive and other funds (7)：

2023 - 2026 CD20陽性T細胞とB細胞に注目した多発性硬化症病態の解明
2017 - 2019 Establishment of world-premier pachymeningitis animal model and development of new therapeutic option targeting TGF-beta.
2016 - 2019 Elucidation of mechanisms for destruction and fixation of glia-syncytium in demyelinating diseases by whole-genome sequencing and immunohistochemical analysis.
2017 - 2018 Elucidating the pathogenesis of demyelinating diseases based on the deletion type copy number variation and the deviated repertoire of gamma delta T cells
2015 - 2017 Investigating the role of mincle in the effector phase of central nervous system autoimmunity

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Papers (42)：

渡邉充, 松尾江梨子, 篠田紘司, 田中栄蔵, 小柳文乃, 福元尚子, 眞崎勝久, 松下拓也, 吉良潤一, 磯部紀子. 多発性硬化症におけるγδ型T細胞の病態関与と治療反応性バイオマーカーとしての有用性の検討. 神経免疫学. 2023. 28. 1. 156-156
田中栄蔵, 渡邉充, 篠田紘司, 眞崎勝久, 松下拓也, 磯部紀子. 多発性硬化症における頭部全脊髄MRIでの多発T2病変とフマル酸ジメチルによる再発抑制効果との関連性の検討. 神経免疫学. 2023. 28. 1. 210-210
田中栄蔵, 渡邉充, 篠田紘司, 眞崎勝久, 松下拓也, 磯部紀子. 多発性硬化症における頭部全脊髄MRIでの多発T2病変とフマル酸ジメチルによる再発抑制効果との関連性の検討. 神経免疫学. 2023. 28. 1. 210-210
篠田紘司, 倉沢亮, 吉村基, 進村光規, 園田啓太, 村松一洋, 高瀬敬一郎. 特徴的な画像所見から診断に至ったWDR45関連神経変性症の一例. 臨床神経学. 2023. 63. 2. 112-112
Koji Shinoda, Rui Li, Ayman Rezk, Ina Mexhitaj, Kristina R Patterson, Mihir Kakara, Leah Zuroff, Jeffrey L Bennett, H-Christian von Büdingen, Robert Carruthers, et al. Differential effects of anti-CD20 therapy on CD4 and CD8 T cells and implication of CD20-expressing CD8 T cells in MS disease activity. Proceedings of the National Academy of Sciences of the United States of America. 2023. 120. 3. e2207291120

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MISC (49)：

篠田紘司. 【免疫性神経疾患(第2版)-基礎・臨床の最新知見-】中枢神経脱髄疾患再発寛解型MSの抗B細胞療法の意義とメカニズム. 日本臨床. 2022. 80. 増刊5 免疫性神経疾患. 162-167
劉景晨, 進村光規, 篠田紘司, 貞島祥子, 園田啓太, 内堀歩, 千葉厚郎, 高瀬敬一郎. COVID-19感染後にギラン・バレー症候群を発症した1例. 臨床神経学. 2021. 61. 12. 890-890
篠田紘司, Li Rui, Rezk Ayman, Bar-Or Amit. 多発性硬化症患者において抗CD20抗体治療が誘導するB細胞再構成とCD20陽性T細胞除去の意義. 神経免疫学. 2021. 26. 1. 111-111
古再麗阿依買買提江, 渡邉充, 篠田紘司, 中村優理, 迫田礼子, 磯部紀子, 松下拓也, 吉良潤一. T細胞受容体γ鎖領域欠失型コピー数変異と多発性硬化症末梢血γδT細胞分画の変化. 臨床神経学. 2021. 61. Suppl. S324-S324
前田泰宏, 渡邉充, 前田教寿, 緒方英紀, 篠田紘司, 岩城徹, 吉良潤一. 免疫抑制薬使用患者に生じた重症水痘・帯状疱疹ウイルス関連脳脊髄炎の1剖検例. 臨床神経学. 2020. 60. 5. 351-357

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Lectures and oral presentations (22)：

Cellular Immune Profiling Pre- and Post-anti-CD20 Therapy Reveals Differential Effects on CD4+ and CD8+ T cells and Implicates CD20+CD8+ T Cells in the Disease Activity of Multiple Sclerosis
(The 13th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis (PACTRIMS) 2021)
Cellular immune profiling Pre- and Post-aCD20 therapy points to differential effects on CD4+ and CD8+ T cells and implicates CD20-expressing CD8+ T cells in MS disease activity
(The 37th Congress of the European Committee for Treatment and Research in Multiple Sclerosis 2021)
Characterization of age-related changes in circulating T cells in multiple sclerosis and normal controls: a pilot study
(MSVirtual 2020 2020)
Resistance of CD11c+ B cells to anti-CD20 depletion with treatment initiation and early preferential repopulation of anti-inflammatory B cells in MS
(MSVirtual 2020 2020)
B cells selectively induce CD8+ MAIT cell effector functions: implications for multiple sclerosis
(Americas Committee for Treatment and Research in Multiple Sclerosis (ACTRIMS) 2020 Forum 2020)

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Education (2)：

2011 - 2015 Kyushu University
2001 - 2007 Kyushu University School of Medicine

Professional career (1)：

Doctor of Philosophy (Medical Science) (Kyushu University)

Work history (8)：

2023/07 - 現在九州大学大学院医学研究院神経内科学特任助教・学術研究員
2022/04 - 2024/09 Iizuka Hospital Department of Neurology
2022/04 - 2023/06 九州大学大学院医学研究院神経内科学共同研究員
2021/04 - 2022/03 Iizuka Hospital Department of Neurology
2018/04 - 2021/03 University of Pennsylvania Department of Neurology, Perelman School of Medicine Postdoctoral Researcher

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Awards (17)：

2024/10 - Japanese Society for Neuroimmunology Research Innovation Award
2020/02 - ACTRIMS 2020 Forum Educational Travel Grant
2019/04 - Japan Society for the Promotion of Science Overseas Research Fellowship
2018/11 - Kanae Memorial Foundation for the Promotion of Medical Science 47th Overseas Research fellowship
2018/03 - the Japanese Society of Neurology Research Fellowship

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Association Membership(s) (7)：

Federation of Clinical Immunology Societies , Japanese Headache Society , Japan Society for Dementia Research , American Academy of Neurology , 日本内科学会 , 日本神経免疫学会 , 日本神経学会

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