Kaya Motoshi

カヤモトシ | Kaya Motoshi

Affiliation and department：
Job title： Assistant professor

Research field (1)： Biophysics

Research keywords (1)： myosin, actin, myoblast, cell fusion, mitochondria, cellular thermodynamics, cytoplasmic viscosity

Research theme for competitive and other funds (11)：

2023 - 2026 骨格筋のしなやかさにおける微小管の役割
2022 - 2025 Elucidating Cellular and Molecular Mechanisms of Myoblast Fusion Using Machine Learning
2022 - 2024 Cooperative functions of myosin molecular ensembles as manifested in information theory.
2020 - 2023 Role of Microtubules in the Muscle Structure-Contraction Relationship
2018 - 2021 A novel super-resolution imaging method for capturing individual molecular dynamics in cardiac myosin ensembles

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Papers (27)：

Motoshi Kaya. Considering the effect of Pi rebinding on myosin dynamics based on the distinct functions of cardiac and skeletal myosin. Frontiers in Physiology. 2025. 16
Eiji Wada, Nao Susumu, Motoshi Kaya, Yukiko K. Hayashi. Characteristics of nuclear architectural abnormalities of myotubes differentiated from LmnaH222P/H222P skeletal muscle cells. In Vitro Cellular & Developmental Biology - Animal. 2024
Yongtae Hwang, Takumi Washio, Toshiaki Hisada, Hideo Higuchi, Motoshi Kaya. A reverse stroke characterizes the force generation of cardiac myofilaments, leading to an understanding of heart function. Proceedings of the National Academy of Sciences. 2021. 118. 23
茅元司. Coordinated Force Generation of Skeletal Myosins. 生物物理(Web). 2019. 59. 5
Yoshimi Kinoshita, Taketoshi Kambara, Kaori Nishikawa, Motoshi Kaya, Hideo Higuchi. Step Sizes and Rate Constants of Single-headed Cytoplasmic Dynein Measured with Optical Tweezers. Scientific Reports. 2018. 8. 1

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MISC (4)：

Seohyun Lee, Motoshi Kaya, Hideo Higuchi. 3P300 Trafficking of membrane protein PAR-1 carried by endocytotic vesicles in cancer cells(27. Bioimaging,Poster,The 52nd Annual Meeting of the Biophysical Society of Japan(BSJ2014)). Seibutsu Butsuri. 2014. 54. supplement1-2. S298-S298
Tomohiro Shima, Kohji Ito, Takahide Kon, Motoshi Kaya, Hideo Higuchi, Kazuo Sutoh. Two Motor Domains of Cytoplasmic Dynein Directly Interact Each Other. BIOPHYSICAL JOURNAL. 2011. 100. 3. 529-530
Nguyen HoaAnh, Kaya Motoshi, Kon Takahide, Sutoh Kazuo, Higuchi Hideo. 2P177 The contribution of individual dynein head to the processive movement generated by two single headed dynein(Molecular motors,Oral Presentations). Seibutsu Butsuri. 2007. 47. S157
Anh H. Nguyen, Motoshi Kaya, Takahide Kon, Kazuo Sutoh, Hideo Higuchi. The contribution of individual dynein head to the processive movement of two single-headed dynein. BIOPHYSICAL JOURNAL. 2007. 526A-526A

Books (3)：

Minorities and small numbers from molecules to organisms in biology : toward a new understanding of biological phenomena
Springer 2018 ISBN:9811320829
少数性生物学
日本評論社 2017 ISBN:4535788162
1分子生物学
化学同人 2014 ISBN:9784759815184

Lectures and oral presentations (24)：

Cooperative functions of skeletal muscle myosin as revealed in information theory.
(2024)
情報量からみるミオシン分子間の協同性
(第101回日本生理学会大会シンポジウム「シンポジウムタイトル:筋生理学研究の最先端:分子、細胞から個体へ」北九州国際会議場 2024)
情報量からみるミオシン分子間の協同性
(第46回日本分子生物学会年会フォーラム「骨格筋のダイナミクスの階層と適応原理」神戸ポートアイランド 2023)
分子レベルでの情報伝達能力の評価から骨格筋ミオシン分子間の協同性を理解する
(第61回日本生物物理学会年会シンポジウム「自発と応答の情報物理学」 2023)
骨格筋ミオシン,心筋ミオシン分子集団の自律特性が骨格筋,心臓収縮を作り出す
(第60回日本生物物理学会シンポジウム:「分子集団,細胞集団が織りなす自律特性:生命機能の理解を目指して」函館アリーナ 2022)

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Education (4)：

1998 - 2004 University of Calgary Department of Mechanical and Manufacturing Engineering
1996 - 1998 University of Iowa
1994 - 1996 Keio University Graduate School of Science and Technology
1990 - 1994 Keio University Faculty of Science and Technology

Work history (1)：

2006/04 - 現在 The University of Tokyo Department of Physics, Graduate School of Science

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